Now showing items 1-20 of 3092

    • The 0.1% of the population with glucokinase monogenic diabetes can be recognized by clinical characteristics in pregnancy: the Atlantic Diabetes in Pregnancy cohort. 

      Chakera, Ali J.; Spyer, G.; Vincent, N.; Ellard, Sian; Hattersley, Andrew T.; Dunne, F. P. (American Diabetes Association, 2014-02)
      Identifying glucokinase monogenic diabetes (GCK-MODY) in pregnancy is important, as management is different from management for other forms of gestational diabetes mellitus (GDM) and there is no increased maternal risk of ...
    • 1-year outcomes of the Xen45 glaucoma implant. 

      Smith, Michael; Charles, Roselin; Byles, Daniel (Nature, 2019-5)
      To describe the 12-month outcomes of the Xen45 glaucoma stent.
    • 10 Years of Improving Pain Assessment Documentation in a Foundation Trust Hospital 

      Murdoch, Julie; Price, Lucy; Cook, Laura; Wassall, Richard; Jackson, Mark (2016-09)
    • 100 years of insulin: celebrating the past, present and future of diabetes therapy 

      Sims, E. K.; Carr, A. L. J.; Oram, R. A.; DiMeglio, L. A.; Evans-Molina, C. (Nature, 2021-07-15)
      The year 2021 marks the centennial of Banting and Best's landmark description of the discovery of insulin. This discovery and insulin's rapid clinical deployment effectively transformed type 1 diabetes from a fatal diagnosis ...
    • 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care - Preliminary Report 

      Smedley, D.; Smith, K. R.; Martin, A.; Thomas, E. A.; McDonagh, E. M.; Cipriani, V.; Ellingford, J. M.; Arno, G.; Tucci, A.; Vandrovcova, J.; Chan, G.; Williams, H. J.; Ratnaike, T.; Wei, W.; Stirrups, K.; Ibanez, K.; Moutsianas, L.; Wielscher, M.; Need, A.; Barnes, M. R.; Vestito, L.; Buchanan, J.; Wordsworth, S.; Ashford, S.; Rehmström, K.; Li, E.; Fuller, G.; Twiss, P.; Spasic-Boskovic, O.; Halsall, S.; Floto, R. A.; Poole, K.; Wagner, A.; Mehta, S. G.; Gurnell, M.; Burrows, N.; James, R.; Penkett, C.; Dewhurst, E.; Gräf, S.; Mapeta, R.; Kasanicki, M.; Haworth, A.; Savage, H.; Babcock, M.; Reese, M. G.; Bale, M.; Baple, E.; Boustred, C.; Brittain, H.; de Burca, A.; Bleda, M.; Devereau, A.; Halai, D.; Haraldsdottir, E.; Hyder, Z.; Kasperaviciute, D.; Patch, C.; Polychronopoulos, D.; Matchan, A.; Sultana, R.; Ryten, M.; Tavares, A. L. T.; Tregidgo, C.; Turnbull, C.; Welland, M.; Wood, S.; Snow, C.; Williams, E.; Leigh, S.; Foulger, R. E.; Daugherty, L. C.; Niblock, O.; Leong, I. U. S.; Wright, C. F.; Davies, J.; Crichton, C.; Welch, J.; Woods, K.; Abulhoul, L.; Aurora, P.; Bockenhauer, D.; Broomfield, A.; Cleary, M. A.; Lam, T.; Dattani, M.; Footitt, E.; Ganesan, V.; Grunewald, S.; Compeyrot-Lacassagne, S.; Muntoni, F.; Pilkington, C.; Quinlivan, R.; Thapar, N.; Wallis, C.; Wedderburn, L. R.; Worth, A.; Bueser, T.; Compton, C.; Deshpande, C.; Fassihi, H.; Haque, E.; Izatt, L.; Josifova, D.; Mohammed, S.; Robert, L.; Rose, S.; Ruddy, D.; Sarkany, R.; Say, G.; Shaw, A. C.; Wolejko, A.; Habib, B.; Burns, G.; Hunter, S.; Grocock, R. J.; Humphray, S. J.; Robinson, P. N.; Haendel, M.; Simpson, M. A.; Banka, S.; Clayton-Smith, J.; Douzgou, S.; Hall, G.; Thomas, H. B.; O'Keefe, R. T.; Michaelides, M.; Moore, A. T.; Malka, S.; Pontikos, N.; Browning, A. C.; Straub, V.; Gorman, G. S.; Horvath, R.; Quinton, R.; Schaefer, A. M.; Yu-Wai-Man, P.; Turnbull, D. M.; McFarland, R.; Taylor, R. W.; O'Connor, E.; Yip, J.; Newland, K.; Morris, H. R.; Polke, J.; Wood, N. W.; Campbell, C.; Camps, C.; Gibson, K.; Koelling, N.; Lester, T.; Németh, A. H.; Palles, C.; Patel, S.; Roy, N. B. A.; Sen, A.; Taylor, J.; Cacheiro, P.; Jacobsen, J. O.; Seaby, E. G.; Davison, V.; Chitty, L.; Douglas, A.; Naresh, K.; McMullan, D.; Ellard, S.; Temple, I. K.; Mumford, A. D.; Wilson, G.; Beales, P.; Bitner-Glindzicz, M.; Black, G.; Bradley, J. R.; Brennan, P.; Burn, J.; Chinnery, P. F.; Elliott, P.; Flinter, F.; Houlden, H.; Irving, M.; Newman, W.; Rahman, S.; Sayer, J. A.; Taylor, J. C.; Webster, A. R.; Wilkie, A. O. M.; Ouwehand, W. H.; Raymond, F. L.; Chisholm, J.; Hill, S.; Bentley, D.; Scott, R. H.; Fowler, T.; Rendon, A.; Caulfield, M. (Massachusetts Medical Society, 2021-11-11)
      BACKGROUND: The U.K. 100,000 Genomes Project is in the process of investigating the role of genome sequencing in patients with undiagnosed rare diseases after usual care and the alignment of this research with health care ...
    • 12 Being Non-Frail and Free From Cardiovascular Disease Reduces COVID-19 Risk in 269,164 Older UK Biobank Participants 

      Masoli, J; Atkins, J; Delgado, J; Pilling, L; Melzer, D (Oxford University Press, 2021-03-01)
      Older adults are at increased risk of COVID-19, resulting in public health shielding measures for all adults over 70 in the UK. Frailty has been proposed for risk stratification in COVID-19 with limited evidence. Cardiovascular ...
    • 14-month old boy with abrupt-onset petechiae and bruising 

      Chanchlani, Neil; Rack, Dan; Hossain, Upal; Leigh, Andrea (BMJ, 2021-02-01)
      A healthy 14-month-old boy presented with a 2-day history of widespread petechiae and bruising. Parents were originally from East Asia, and the boy was born in the UK. He was clinically well with no organomegaly. He had a ...
    • 18F-FDG PET in the Diagnosis of Vascular Prosthetic Graft Infection: A Diagnostic Test Accuracy Meta-Analysis. 

      Rojoa, D.; Kontopodis, N.; Antoniou, Stavros A.; Ioannou, C. V.; Antoniou, G. A. (Elsevier, 2018-09-18)
      For the diagnosis of vascular prosthetic graft infection (VPGI), an intra-operative peri-graft biopsy is often required. Controversy exists regarding the use of imaging techniques in the diagnostic process. This study aimed ...
    • 2014 European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children 

      Lazarus, J.; Brown, R. S.; Daumerie, C.; Hubalewska-Dydejczyk, A.; Negro, R.; Vaidya, Bijay (Karger, 2014-06-01)
      This guideline has been produced as the official statement of the European Thyroid Association guideline committee. Subclinical hypothyroidism (SCH) in pregnancy is defined as a thyroid-stimulating hormone (TSH) level above ...
    • 27 years of prenatal diagnosis for Huntington disease in the United Kingdom. 

      Turnpenny, Peter D. (Nature, 2018-12-14)
      There is little long-term, population-based data on uptake of prenatal diagnosis for Huntington disease (HD), a late-onset autosomal dominant neurodegenerative disorder, and the effect of the availability of preimplantation ...
    • 3-phase Technicium-99m bone scanning in patients with pain in the hip region after cemented total hip replacement: a multicentre series of 100 cases. 

      Hill, Daniel S; Naim, Soulat; Powell, Roy; Kinsella, Denis; Toms, Andrew; Howell, Jonathan (Wichtig, 2017-11-21)
      The aim of this study was to assess the benefit of a Technetium-99M (HDP) 3-phase bone scan (TPBS) as an additional diagnostic test in the evaluation of pain in the hip region following cemented total hip replacement (THR) ...
    • 325 Pretibial Injury and 1 Year Mortality 

      Peberdy, D (Wiley, 2021-10-12)
    • 5-hydroxymethylcytosine is highly dynamic across human fetal brain development. 

      Spiers, H.; Hannon, Eilis; Schalkwyk, L. C.; Bray, N. J.; Mill, Jonathan (BioMed Central, 2017-09-18)
      Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during ...
    • 50 years of total knee arthroplasty 

      Patel, Nimesh; Waterson, Hugh B.; Phillips, Jonathan R. A. (British Editorial Society of Bone & Joint Surgery, 2019-05)
    • 52 I’m on the Floor and Can’t Get up and it’s Really Annoying: A Qualitative Investigation of Patient and Staff Perceptions of Options for Getting up From the Floor Following A Fall 

      Swancutt, D; Hope, S V; Kent, B; Robinson, M; Goodwin, V (Oxford University Press, 2021-03-01)
      Falls are the most common reason for ambulance call-outs resulting in non-conveyance. Even in the absence of injury, only half of those who have fallen can get themselves up off the floor. Many remain there for over an ...
    • A 60 year history of recurrent hypoglycaemia 

      Foteinopoulou, E.; Colclough, Kevin; Strachan, M. (BioScientifica, 2018-04-09)
    • 601 The Effect of the COVID-19 Pandemic on Hip Fracture Mortality in The South West of England 

      Spolton-Dean, C; Kent, B; Ball, T; Middleton, R; Marusza, C; Hinsley, H; King, A; Ayeko, S (Wiley, 2021-09-06)
    • 8b.07: Results from the Uk Renal Denervation Affiliation- 246 Cases from 17 Centres 

      Sharp, Andrew; Hameed, A.; Nightingale, A.; Martin, U.; Mark, P.; McKane, W.; Cunnington, M.; Lobo, M.; Mahadevan, K.; Richardson, T.; Gerber, R.; ClifFord, Pete; Burchell, A.; Doulton, T.; Dimario, C.; Thackray, S.; Redwood, S.; Davies, J.; Antonios, T.; Dasgupta, I. (Wolters Kluwer, 2015-06)
      OBJECTIVE: To describe the UK experience with Renal Denervation (RDN). DESIGN AND METHOD: RDN may lower blood pressure (BP) in people with resistant hypertension.The UK Renal Denervation Affiliation is an independent, ...
    • A 2021 consensus statement on osteotomies around the knee by the UK Knee Osteotomy consensus Group (KOG) 

      Snow, M.; Jermain, P.; Mandalia, V.; Murray, J.; Khakha, R.; McNicholas, M.; Dawson, M. (Elsevier, 2021-09-22)
      BACKGROUND: There are significant deficiencies in the evidence base of modern-day osteotomy which result in significant variation in practice between surgeons. The purpose of this statement was to develop a consensus ...