Now showing items 1-20 of 3226

    • The 0.1% of the population with glucokinase monogenic diabetes can be recognized by clinical characteristics in pregnancy: the Atlantic Diabetes in Pregnancy cohort. 

      Chakera, Ali J.; Spyer, G.; Vincent, N.; Ellard, Sian; Hattersley, Andrew T.; Dunne, F. P. (American Diabetes Association, 2014-02)
      Identifying glucokinase monogenic diabetes (GCK-MODY) in pregnancy is important, as management is different from management for other forms of gestational diabetes mellitus (GDM) and there is no increased maternal risk of ...
    • 1-year outcomes of the Xen45 glaucoma implant. 

      Smith, Michael; Charles, Roselin; Byles, Daniel (Nature, 2019-5)
      To describe the 12-month outcomes of the Xen45 glaucoma stent.
    • 10 Years of Improving Pain Assessment Documentation in a Foundation Trust Hospital 

      Murdoch, Julie; Price, Lucy; Cook, Laura; Wassall, Richard; Jackson, Mark (2016-09)
    • 100 years of insulin: celebrating the past, present and future of diabetes therapy 

      Sims, E. K.; Carr, A. L. J.; Oram, R. A.; DiMeglio, L. A.; Evans-Molina, C. (Nature, 2021-07-15)
      The year 2021 marks the centennial of Banting and Best's landmark description of the discovery of insulin. This discovery and insulin's rapid clinical deployment effectively transformed type 1 diabetes from a fatal diagnosis ...
    • 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care - Preliminary Report 

      Smedley, D.; Smith, K. R.; Martin, A.; Thomas, E. A.; McDonagh, E. M.; Cipriani, V.; Ellingford, J. M.; Arno, G.; Tucci, A.; Vandrovcova, J.; Chan, G.; Williams, H. J.; Ratnaike, T.; Wei, W.; Stirrups, K.; Ibanez, K.; Moutsianas, L.; Wielscher, M.; Need, A.; Barnes, M. R.; Vestito, L.; Buchanan, J.; Wordsworth, S.; Ashford, S.; Rehmström, K.; Li, E.; Fuller, G.; Twiss, P.; Spasic-Boskovic, O.; Halsall, S.; Floto, R. A.; Poole, K.; Wagner, A.; Mehta, S. G.; Gurnell, M.; Burrows, N.; James, R.; Penkett, C.; Dewhurst, E.; Gräf, S.; Mapeta, R.; Kasanicki, M.; Haworth, A.; Savage, H.; Babcock, M.; Reese, M. G.; Bale, M.; Baple, E.; Boustred, C.; Brittain, H.; de Burca, A.; Bleda, M.; Devereau, A.; Halai, D.; Haraldsdottir, E.; Hyder, Z.; Kasperaviciute, D.; Patch, C.; Polychronopoulos, D.; Matchan, A.; Sultana, R.; Ryten, M.; Tavares, A. L. T.; Tregidgo, C.; Turnbull, C.; Welland, M.; Wood, S.; Snow, C.; Williams, E.; Leigh, S.; Foulger, R. E.; Daugherty, L. C.; Niblock, O.; Leong, I. U. S.; Wright, C. F.; Davies, J.; Crichton, C.; Welch, J.; Woods, K.; Abulhoul, L.; Aurora, P.; Bockenhauer, D.; Broomfield, A.; Cleary, M. A.; Lam, T.; Dattani, M.; Footitt, E.; Ganesan, V.; Grunewald, S.; Compeyrot-Lacassagne, S.; Muntoni, F.; Pilkington, C.; Quinlivan, R.; Thapar, N.; Wallis, C.; Wedderburn, L. R.; Worth, A.; Bueser, T.; Compton, C.; Deshpande, C.; Fassihi, H.; Haque, E.; Izatt, L.; Josifova, D.; Mohammed, S.; Robert, L.; Rose, S.; Ruddy, D.; Sarkany, R.; Say, G.; Shaw, A. C.; Wolejko, A.; Habib, B.; Burns, G.; Hunter, S.; Grocock, R. J.; Humphray, S. J.; Robinson, P. N.; Haendel, M.; Simpson, M. A.; Banka, S.; Clayton-Smith, J.; Douzgou, S.; Hall, G.; Thomas, H. B.; O'Keefe, R. T.; Michaelides, M.; Moore, A. T.; Malka, S.; Pontikos, N.; Browning, A. C.; Straub, V.; Gorman, G. S.; Horvath, R.; Quinton, R.; Schaefer, A. M.; Yu-Wai-Man, P.; Turnbull, D. M.; McFarland, R.; Taylor, R. W.; O'Connor, E.; Yip, J.; Newland, K.; Morris, H. R.; Polke, J.; Wood, N. W.; Campbell, C.; Camps, C.; Gibson, K.; Koelling, N.; Lester, T.; Németh, A. H.; Palles, C.; Patel, S.; Roy, N. B. A.; Sen, A.; Taylor, J.; Cacheiro, P.; Jacobsen, J. O.; Seaby, E. G.; Davison, V.; Chitty, L.; Douglas, A.; Naresh, K.; McMullan, D.; Ellard, S.; Temple, I. K.; Mumford, A. D.; Wilson, G.; Beales, P.; Bitner-Glindzicz, M.; Black, G.; Bradley, J. R.; Brennan, P.; Burn, J.; Chinnery, P. F.; Elliott, P.; Flinter, F.; Houlden, H.; Irving, M.; Newman, W.; Rahman, S.; Sayer, J. A.; Taylor, J. C.; Webster, A. R.; Wilkie, A. O. M.; Ouwehand, W. H.; Raymond, F. L.; Chisholm, J.; Hill, S.; Bentley, D.; Scott, R. H.; Fowler, T.; Rendon, A.; Caulfield, M. (Massachusetts Medical Society, 2021-11-11)
      BACKGROUND: The U.K. 100,000 Genomes Project is in the process of investigating the role of genome sequencing in patients with undiagnosed rare diseases after usual care and the alignment of this research with health care ...
    • 12 Being Non-Frail and Free From Cardiovascular Disease Reduces COVID-19 Risk in 269,164 Older UK Biobank Participants 

      Masoli, J; Atkins, J; Delgado, J; Pilling, L; Melzer, D (Oxford University Press, 2021-03-01)
      Older adults are at increased risk of COVID-19, resulting in public health shielding measures for all adults over 70 in the UK. Frailty has been proposed for risk stratification in COVID-19 with limited evidence. Cardiovascular ...
    • 122 Tetanus Prophylaxis for Injuries Referred to a Plastic Surgery Service 

      Stark, D.; Nagrath, N. (Wiley, 2022-02-28)
      To ascertain whether there is appropriate documentation of tetanus immunisation status. To determine whether appropriate tetanus prophylaxis is offered to those with an incomplete or unknown immunisation history for tetanus ...
    • 130 Paediatric Hand Fractures Requiring Surgery – the Results of a Bespoke Hand Surgery Service 

      Donnachie, D.; Yim, G.; Watts, A. (Wiley, 2022-02-28)
      To evaluate the management of The Royal Devon and Exeter Hospital (RD&E) bespoke hand surgery service on paediatric closed hand fractures. In particular, an assessment against The British Society for Surgery of the ...
    • 14-month old boy with abrupt-onset petechiae and bruising 

      Chanchlani, Neil; Rack, Dan; Hossain, Upal; Leigh, Andrea (BMJ, 2021-02-01)
      A healthy 14-month-old boy presented with a 2-day history of widespread petechiae and bruising. Parents were originally from East Asia, and the boy was born in the UK. He was clinically well with no organomegaly. He had a ...
    • 157 Diagnostic Test Accuracy of Artificial Intelligence Models Used in Cross-Sectional Radiological Imaging of Surgical Pathology in the Abdominopelvic Cavity: A Systematic Review 

      Fowler, G.E.; Blencowe, N.S.; Hardacre, C.; Callaway, M.P.; Smart, N.J.; Macefield, R.C. (Wiley, 2022-02-28)
      Medical imaging is important for diagnostic, prognostic, and management decisions. It is reliant on an increasingly limited number of interpreters. A developing interest has explored how artificial intelligence (AI) research ...
    • 18F-FDG PET in the Diagnosis of Vascular Prosthetic Graft Infection: A Diagnostic Test Accuracy Meta-Analysis. 

      Rojoa, D.; Kontopodis, N.; Antoniou, Stavros A.; Ioannou, C. V.; Antoniou, G. A. (Elsevier, 2018-09-18)
      For the diagnosis of vascular prosthetic graft infection (VPGI), an intra-operative peri-graft biopsy is often required. Controversy exists regarding the use of imaging techniques in the diagnostic process. This study aimed ...
    • 2014 European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children 

      Lazarus, J.; Brown, R. S.; Daumerie, C.; Hubalewska-Dydejczyk, A.; Negro, R.; Vaidya, Bijay (Karger, 2014-06-01)
      This guideline has been produced as the official statement of the European Thyroid Association guideline committee. Subclinical hypothyroidism (SCH) in pregnancy is defined as a thyroid-stimulating hormone (TSH) level above ...
    • 218 Compliance With the British Society for Surgery of the Hand (BSSH) Guidelines on the Management of Open Hand Fractures Audit 

      John, H.; Nagrath, N. (Wiley, 2022-02-28)
      British Society of Surgery of the Hand (BSSH) have defined standards for managing open hand fractures. We intended to ascertain our and referring peripheral units’ adherence with BSSH’s standards of care in managing open ...
    • 266 Improving Management of Women Presenting with Groin Hernias at Royal Devon and Exeter Hospital (RD&E) 

      Chillarge, G. (Wiley, 2022-02-28)
      Determine the percentage of women with groin hernia undergoing laparoscopic repair at RD&E hospital and if it was offered during clinic visit.The lifetime risk of groin hernia in women is 3–5.8%. The incidence of missed ...
    • 268 Improve Clerking of Vascular Patients at Royal Devon and Exeter (RDE) Hospital Presenting with Acute Limb Ischaemia (ALI) Using Standardized Electronic Proforma 

      Chillarge, G.; Abouelella, Y.; Burton, H. (Wiley, 2022-02-28)
      Improve clerking of vascular patients at Royal Devon and Exeter (RDE) hospital presenting with acute limb ischaemia (ALI) using standardized electronic proforma.Analysis of clerking notes of patients presenting to vascular ...
    • 27 years of prenatal diagnosis for Huntington disease in the United Kingdom. 

      Turnpenny, Peter D. (Nature, 2018-12-14)
      There is little long-term, population-based data on uptake of prenatal diagnosis for Huntington disease (HD), a late-onset autosomal dominant neurodegenerative disorder, and the effect of the availability of preimplantation ...
    • 3-phase Technicium-99m bone scanning in patients with pain in the hip region after cemented total hip replacement: a multicentre series of 100 cases. 

      Hill, Daniel S; Naim, Soulat; Powell, Roy; Kinsella, Denis; Toms, Andrew; Howell, Jonathan (Wichtig, 2017-11-21)
      The aim of this study was to assess the benefit of a Technetium-99M (HDP) 3-phase bone scan (TPBS) as an additional diagnostic test in the evaluation of pain in the hip region following cemented total hip replacement (THR) ...
    • 325 Pretibial Injury and 1 Year Mortality 

      Peberdy, D (Wiley, 2021-10-12)
    • 368 Challenges Moving to a Fully Electronic System: An Audit 

      John, H.; Donnachie, D.; Shapev, M. (Wiley, 2022-02-28)
      In October 2020, our hospital moved to an all-online clinical record keeping system, resulting in clinicians becoming responsible for electronically requesting follow up appointments at the time of each clinical encounter. ...
    • 5-hydroxymethylcytosine is highly dynamic across human fetal brain development. 

      Spiers, H.; Hannon, Eilis; Schalkwyk, L. C.; Bray, N. J.; Mill, Jonathan (BioMed Central, 2017-09-18)
      Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during ...