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The 0.1% of the population with glucokinase monogenic diabetes can be recognized by clinical characteristics in pregnancy: the Atlantic Diabetes in Pregnancy cohort.
(American Diabetes Association, 2014-02)Identifying glucokinase monogenic diabetes (GCK-MODY) in pregnancy is important, as management is different from management for other forms of gestational diabetes mellitus (GDM) and there is no increased maternal risk of ... -
1-year outcomes of the Xen45 glaucoma implant.
(Nature, 2019-5)To describe the 12-month outcomes of the Xen45 glaucoma stent. -
100 years of insulin: celebrating the past, present and future of diabetes therapy
(Nature, 2021-07-15)The year 2021 marks the centennial of Banting and Best's landmark description of the discovery of insulin. This discovery and insulin's rapid clinical deployment effectively transformed type 1 diabetes from a fatal diagnosis ... -
12 Being Non-Frail and Free From Cardiovascular Disease Reduces COVID-19 Risk in 269,164 Older UK Biobank Participants
(Oxford University Press, 2021-03-01)Older adults are at increased risk of COVID-19, resulting in public health shielding measures for all adults over 70 in the UK. Frailty has been proposed for risk stratification in COVID-19 with limited evidence. Cardiovascular ... -
14 month old boy with abrupt-onset petechiae and bruising
(BMJ, 2019-06-05) -
14-month old boy with abrupt-onset petechiae and bruising
(BMJ, 2021-02-01)A healthy 14-month-old boy presented with a 2-day history of widespread petechiae and bruising. Parents were originally from East Asia, and the boy was born in the UK. He was clinically well with no organomegaly. He had a ... -
18F-FDG PET in the Diagnosis of Vascular Prosthetic Graft Infection: A Diagnostic Test Accuracy Meta-Analysis.
(Elsevier, 2018-09-18)For the diagnosis of vascular prosthetic graft infection (VPGI), an intra-operative peri-graft biopsy is often required. Controversy exists regarding the use of imaging techniques in the diagnostic process. This study aimed ... -
2014 European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children
(Karger, 2014-06-01)This guideline has been produced as the official statement of the European Thyroid Association guideline committee. Subclinical hypothyroidism (SCH) in pregnancy is defined as a thyroid-stimulating hormone (TSH) level above ... -
27 years of prenatal diagnosis for Huntington disease in the United Kingdom.
(Nature, 2018-12-14)There is little long-term, population-based data on uptake of prenatal diagnosis for Huntington disease (HD), a late-onset autosomal dominant neurodegenerative disorder, and the effect of the availability of preimplantation ... -
3-phase Technicium-99m bone scanning in patients with pain in the hip region after cemented total hip replacement: a multicentre series of 100 cases.
(Wichtig, 2017-11-21)The aim of this study was to assess the benefit of a Technetium-99M (HDP) 3-phase bone scan (TPBS) as an additional diagnostic test in the evaluation of pain in the hip region following cemented total hip replacement (THR) ... -
5-hydroxymethylcytosine is highly dynamic across human fetal brain development.
(BioMed Central, 2017-09-18)Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during ... -
50 years of total knee arthroplasty
(British Editorial Society of Bone & Joint Surgery, 2019-05) -
52 I’m on the Floor and Can’t Get up and it’s Really Annoying: A Qualitative Investigation of Patient and Staff Perceptions of Options for Getting up From the Floor Following A Fall
(Oxford University Press, 2021-03-01)Falls are the most common reason for ambulance call-outs resulting in non-conveyance. Even in the absence of injury, only half of those who have fallen can get themselves up off the floor. Many remain there for over an ... -
A 60 year history of recurrent hypoglycaemia
(BioScientifica, 2018-04-09) -
8b.07: Results from the Uk Renal Denervation Affiliation- 246 Cases from 17 Centres
(Wolters Kluwer, 2015-06)OBJECTIVE: To describe the UK experience with Renal Denervation (RDN). DESIGN AND METHOD: RDN may lower blood pressure (BP) in people with resistant hypertension.The UK Renal Denervation Affiliation is an independent, ... -
A dosimetric study to improve the quality of nodal radiotherapy in breast cancer
(British Institute of Radiology, 2021-08-13)OBJECTIVES: Field-based planning for regional nodal breast radiotherapy (RT) used to be standard practice. This study evaluated a field-based posterior axillary boost (PAB) and two forward-planned intensity-modulated RT ... -
A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor
(PLoS One, 2021-06-10)Frozen shoulder is a painful condition that often requires surgery and affects up to 5% of individuals aged 40–60 years. Little is known about the causes of the condition, but diabetes is a strong risk factor. To begin to ... -
A hemizygous mutation in the FOXP3 gene (IPEX syndrome) resulting in recurrent X-linked fetal hydrops: a case report
(Springer, 2021-02-26)Fetal hydrops is excessive extravasation of fluid into the third space in a fetus, which could be due to a wide differential of underlying pathology. IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) ...