Now showing items 1-3 of 3

    • Deep and Frequent Phenotyping study protocol: an observational study in prodromal Alzheimer's disease 

      Ballard, Clive (BMJ, 2019-03-23)
      Introduction: Recent failures of potential novel therapeutics for Alzheimer's disease (AD) have prompted a drive towards clinical studies in prodromal or preclinical states. However, carrying out clinical trials in early ...
    • Mild cognitive impairment: the Manchester consensus 

      Ballard, Clive (Silverchair, 2021-01-08)
      Given considerable variation in diagnostic and therapeutic practice, there is a need for national guidance on the use of neuroimaging, fluid biomarkers, cognitive testing, follow-up and diagnostic terminology in mild ...
    • Transcriptional Signatures of Tau and Amyloid Neuropathology 

      Hannon, Eilis; Jeffries, A. R.; Walker, E.; Randall, Andrew; Moore, K. A.; O'Neill, P.; Lunnon, Katie; Mill, Jonathan (Elsevier Science, 2020-02-11)
      Alzheimer's disease (AD) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. We use transgenic mice harboring human tau (rTg4510) and amyloid ...