Browsing by Issue Date
Now showing items 1-20 of 3226
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The relationship between cleavage, DNA replication, and gene expression in the mouse 2-cell embryo.
(Development, 1984-02)The 2-cell stage of mouse embryogenesis is characterized by two phases of alpha-amanitin-sensitive polypeptide synthetic activity, which appear to mark the first major expression of the embryonic genome, as assessed by ... -
Prediction of hypoxaemia at high altitude in children with cystic fibrosis.
(BMJ, 1994-01-01)To assess the usefulness of a hypoxic challenge in a laboratory at sea level in predicting acute desaturation at altitude in children with lung disease. -
High-strength pancreatic enzyme supplements and large-bowel stricture in cystic fibrosis.
(ScienceDirect, 1994-01-08) -
Colonic stricture in a boy with cystic fibrosis.
(BMJ, 1995-05)Many problems may arise within the gastrointestinal tract of patients with cystic fibrosis. We report a new cause of subacute intestinal obstruction due to a fibrotic stricture of the ascending colon in a child with cystic ... -
Subclinical colonic thickening.
(Sage, 1996) -
Antidepressant prescribing prior to suicide: Role of doctors
(Cambridge University Press, 1996-05-01)The pharmacological treatment of depression and the time elapsed since last seen by a doctor were investigated among 507 adults who subsequently killed themselves. The proportion of people consulting a general practitioner ... -
Four-layer bandaging and healing rates of venous leg ulcers
(Mark Allen Group, 1996-05-01)This paper reports the healing rates of venous leg ulcers in a community setting (Exeter and District Community Health Services NHS Trust) using the Charing Cross four-layer compression system. We report on 514 venous leg ... -
Venous Ulceration may be a familial disease
(British Association of Dermatologists, 1996-07-01) -
Immunohistochemical detection of p53 and c-erbB-2 in oesophageal carcinoma; no correlation with prognosis
(Elsevier, 1997-02-01)TNM staging of oesophageal cancer provides significant prognostic information but its clinical impact is limited as many patients present with advanced disease (i.e. T3N1). Additional prognostic markers may help separate ... -
A comparative study of treadmill tests and heel raising exercise for peripheral arterial disease
(Elsevier, 1997-03-01)OBJECTIVES: This two part study validated a 1 min treadmill exercise test and compared this with simple heel raising exercise. METHODS: In an initial study of 24 claudicants (aged 43-79, median 63 years), ankle pressures ... -
Validation of current practice and a near patient testing method for oral-anticoagulant control in general practice
(Sage, 1997-12-01)When oral anticoagulant control is monitored in general practice, venous blood samples are usually transported to a central laboratory for determination of international normalized ratio (INR). An alternative is near patient ... -
Sudden death associated with group A streptococcal infection in an 8-year-old girl with undiagnosed hypertrophic cardiomyopathy.
(BMJ, 1998-11)An 8-year-old girl died suddenly without prior symptoms. Post-mortem examination identified both systemic group A streptococcal infection and hypertrophic cardiomyopathy. She had no history of cardiac symptoms and was not ... -
Health-related quality-of-life measures for children.
(Wiley, 1999)Our purpose is to report the development and psychometric properties of a generic computer-delivered measure of health-related quality of life (HRQL) suitable for children aged 6 to 11 years, the Exeter HRQL scale (EHRQL). ... -
Transport and temperature effects on measurement of serum and plasma potassium
(Sage, 1999-07-01)Transport of blood samples from general practice to a central laboratory can result in spuriously high or low potassium concentrations. The importance of this phenomenon was studied in a general practice serving a population ... -
Behavioural changes in the rat following infection with varicella-zoster virus
(Microbiology Society, 1999-09-01)Following the establishment of a chronic varicella-zoster virus infection in the rat, behavioural allodynia and hyperalgesia were observed in the injected, but not the contralateral hind limb up to 33 days post-infection. ... -
Living with chronic illness: a transitional model of coping
(MAG Online Library, 2000-01) -
A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria.
(Springer, 2000-02)Patients with glucokinase mutations are characterised by mild, persistent fasting hyperglycaemia, a small increment in glucose in response to an oral load and a dominant family history. These patients frequently present ... -
Predictive genetic testing in diabetes: a case study of multiple perspectives.
(Sage, 2000-03)Genetic testing is now possible in maturity onset diabetes of the young (MODY), an unusual genetic subtype of diabetes. To date, there has been no research into the implications of genetic testing for MODY families. The ... -
Sex and relationships following childbirth: a first report from general practice of 131 couples
(Royal College of General Practitioners, 2000-04-06)Changes in a couple's sexual relationship following childbirth may be more significant than previous studies have suggested. Around 50% of first-time parents in this study described their sex life as 'poor' or 'not very ... -
Suicide in the farming community: methods used and contact with health services
(BMJ Publishing Group, 2000-08-10)Farmers have a high rate of suicide (1% of suicides in England and Wales). This study sought to test whether farmers would be less likely to have been in contact with primary or mental health services before death due to ...