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Test, A.; Test, B. (01/01/2021)

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The relationship between cleavage, DNA replication, and gene expression in the mouse 2-cell embryo.

Bolton, V.N.; Oades, Patrick; Johnson, M.H. (Development, 1984-02)

The 2-cell stage of mouse embryogenesis is characterized by two phases of alpha-amanitin-sensitive polypeptide synthetic activity, which appear to mark the first major expression of the embryonic genome, as assessed by ...

Prediction of hypoxaemia at high altitude in children with cystic fibrosis.

Oades, Patrick; Buchdahl, R.M.; Bush, A. (BMJ, 1994-01-01)

To assess the usefulness of a hypoxic challenge in a laboratory at sea level in predicting acute desaturation at altitude in children with lung disease.

High-strength pancreatic enzyme supplements and large-bowel stricture in cystic fibrosis.

Oades, Patrick; Bush, A.; Ong, P.S.; Brereton, R.J. (ScienceDirect, 1994-01-08)

Colonic stricture in a boy with cystic fibrosis.

Ong, P.S.; Oades, Patrick; Bush, A.; Brereton, R.J. (BMJ, 1995-05)

Many problems may arise within the gastrointestinal tract of patients with cystic fibrosis. We report a new cause of subacute intestinal obstruction due to a fibrotic stricture of the ascending colon in a child with cystic ...

Subclinical colonic thickening.

Oades, Patrick; Rosenthal, M.; Mac Sweeney, E.J.; Bush, A. (Sage, 1996)

Sudden death associated with group A streptococcal infection in an 8-year-old girl with undiagnosed hypertrophic cardiomyopathy.

Bragonier, R.; Oades, Patrick (BMJ, 1998-11)

An 8-year-old girl died suddenly without prior symptoms. Post-mortem examination identified both systemic group A streptococcal infection and hypertrophic cardiomyopathy. She had no history of cardiac symptoms and was not ...

Health-related quality-of-life measures for children.

Eiser, C.; Cotter, I.; Oades, Patrick; Seamark, D.; Smith, R. (Wiley, 1999)

Our purpose is to report the development and psychometric properties of a generic computer-delivered measure of health-related quality of life (HRQL) suitable for children aged 6 to 11 years, the Exeter HRQL scale (EHRQL). ...

Behavioural changes in the rat following infection with varicella-zoster virus

Wallace, Christopher G; Fleetwood-Walker, S. M.; Dalziel, R. G.; Kelly, B. G.; Blackburn-Munro, G.; Quinn, J. P.; Fiskerstrand, C. E.; Nash, A. A. (Microbiology Society, 1999-09-01)

Following the establishment of a chronic varicella-zoster virus infection in the rat, behavioural allodynia and hyperalgesia were observed in the injected, but not the contralateral hind limb up to 33 days post-infection. ...

Living with chronic illness: a transitional model of coping

Jarrett, Louise (MAG Online Library, 2000-01)

A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria.

Ellard, Sian; Beards, F.; Allen, Louisa; Shepherd, Maggie; Ballantyne, E.; Harvey, R.; Hattersley, Andrew T. (Springer, 2000-02)

Patients with glucokinase mutations are characterised by mild, persistent fasting hyperglycaemia, a small increment in glucose in response to an oral load and a dominant family history. These patients frequently present ...

Predictive genetic testing in diabetes: a case study of multiple perspectives.

Shepherd, Maggie; Hattersley, Andrew T.; Sparkes, A. C. (Sage, 2000-03)

Genetic testing is now possible in maturity onset diabetes of the young (MODY), an unusual genetic subtype of diabetes. To date, there has been no research into the implications of genetic testing for MODY families. The ...

beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.

Frayling, Timothy M.; Evans, J. C.; Bulman, M. P.; Pearson, E. R.; Allen, Louisa; Owen, K.; Bingham, Coralie; Hannemann, Michael; Shepherd, Maggie; Ellard, Sian; Hattersley, Andrew T. (Highwire, 2001-02)

beta-Cell transcription factor genes are important in the pathophysiology of the beta-cell, with mutations in hepatocyte nuclear factor (HNF)-1alpha, HNF-4alpha, insulin promoter factor (IPF)-1, HNF-1beta, and NeuroD1/BETA2, ...

Treatment demands and differential treatment of patients with cystic fibrosis and their siblings: patient, parent and sibling accounts.

Foster, C.; Eiser, C.; Oades, Patrick; Sheldon, Christopher David; Tripp, J.H.; Goldman, P.; Rice, S.; Trott, J. (Wiley, 2001-07)

Cystic fibrosis (CF) is a progressive disease with no known cure. Advances in diagnosis and treatment have resulted in patients living longer and thus families live with the illness for longer. Treatments are becoming ...