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    • Elevated circulating follistatin associates with an increased risk of type 2 diabetes 

      Wu, C.; Borné, Y.; Gao, R.; López Rodriguez, M.; Roell, W. C.; Wilson, J. M.; Regmi, A.; Luan, C.; Aly, D. M.; Peter, A.; Machann, J.; Staiger, H.; Fritsche, A.; Birkenfeld, A. L.; Tao, R.; Wagner, R.; Canouil, M.; Hong, M. G.; Schwenk, J. M.; Ahlqvist, E.; Kaikkonen, M. U.; Nilsson, P.; Shore, A. C.; Khan, F.; Natali, A.; Melander, O.; Orho-Melander, M.; Nilsson, J.; Häring, H. U.; Renström, E.; Wollheim, C. B.; Engström, G.; Weng, J.; Pearson, E. R.; Franks, P. W.; White, M. F.; Duffin, K. L.; Vaag, A. A.; Laakso, M.; Stefan, N.; Groop, L.; De Marinis, Y. (Nature, 2021-11-10)
      The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with incident T2D and mechanisms involved. ...