Now showing items 1-5 of 5

    • Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion. 

      Yaghootkar, Hanieh; Stancáková, A.; Freathy, Rachel M.; Vangipurapu, J.; Weedon, M. N.; Xie, W.; Wood, A. R.; Ferrannini, E.; Mari, A.; Ring, S. M.; Lawlor, D. A.; Davey Smith, G.; Jørgensen, T.; Hansen, T.; Pedersen, O.; Steinthorsdottir, V.; Guðbjartsson, D. F.; Thorleifsson, G.; Thorsteinsdottir, U.; Stefansson, K.; Hattersley, Andrew T.; Walker, M.; Morris, A. D.; McCarthy, M. I.; Palmer, C. N. A.; Laakso, M.; Frayling, Timothy M. (American Diabetes Association, 2015-06)
      A recent study identified a low-frequency variant at CCND2 associated with lower risk of type 2 diabetes, enhanced insulin response to a glucose challenge, higher height, and, paradoxically, higher BMI. We aimed to replicate ...
    • Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium. 

      Koivula, R. W.; Heggie, A.; Barnett, A.; Cederberg, H.; Hansen, T. H.; Koopman, A. D.; Ridderstråle, M.; Rutters, F.; Vestergaard, H.; Gupta, R.; Herrgård, S.; Heymans, M. W.; Perry, Mandy; Rauh, S.; Siloaho, M.; Teare, H. J. A.; Thorand, B.; Bell, J.; Brunak, S.; Frost, G.; Jablonka, B.; Mari, A.; McDonald, Timothy J.; Dekker, J. M.; Hansen, T. V. O.; Hattersley, Andrew T.; Laakso, M.; Pedersen, O.; Koivisto, V.; Ruetten, H.; Walker, M.; Pearson, E. R.; Franks, P. W. (Springer, 2014-06)
      The DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout ...
    • Elevated circulating follistatin associates with an increased risk of type 2 diabetes 

      Wu, C.; Borné, Y.; Gao, R.; López Rodriguez, M.; Roell, W. C.; Wilson, J. M.; Regmi, A.; Luan, C.; Aly, D. M.; Peter, A.; Machann, J.; Staiger, H.; Fritsche, A.; Birkenfeld, A. L.; Tao, R.; Wagner, R.; Canouil, M.; Hong, M. G.; Schwenk, J. M.; Ahlqvist, E.; Kaikkonen, M. U.; Nilsson, P.; Shore, A. C.; Khan, F.; Natali, A.; Melander, O.; Orho-Melander, M.; Nilsson, J.; Häring, H. U.; Renström, E.; Wollheim, C. B.; Engström, G.; Weng, J.; Pearson, E. R.; Franks, P. W.; White, M. F.; Duffin, K. L.; Vaag, A. A.; Laakso, M.; Stefan, N.; Groop, L.; De Marinis, Y. (Nature, 2021-11-10)
      The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with incident T2D and mechanisms involved. ...
    • Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance. 

      Patel, K. A.; Kettunen, J.; Laakso, M.; Stančáková, A.; Laver, T. W.; Colclough, Kevin; Johnson, M. B.; Abramowicz, M.; Groop, L.; Miettinen, P. J.; Shepherd, Maggie; Flanagan, S. E.; Ellard, Sian; Inagaki, N.; Hattersley, Andrew T.; Tuomi, T.; Cnop, M.; Weedon, M. N. (Nature, 2017-10-12)
      Finding new causes of monogenic diabetes helps understand glycaemic regulation in humans. To find novel genetic causes of maturity-onset diabetes of the young (MODY), we sequenced MODY cases with unknown aetiology and ...
    • Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study 

      Tura, A.; Grespan, E.; Göbl, C. S.; Koivula, R. W.; Franks, P. W.; Pearson, E. R.; Walker, M.; Forgie, I. M.; Giordano, G. N.; Pavo, I.; Ruetten, H.; Dermitzakis, E. T.; McCarthy, M. I.; Pedersen, O.; Schwenk, J. M.; Adamski, J.; De Masi, F.; Tsirigos, K. D.; Brunak, S.; Viñuela, A.; Mahajan, A.; McDonald, T. J.; Kokkola, T.; Vangipurapu, J.; Cederberg, H.; Laakso, M.; Rutters, F.; Elders, P. J. M.; Koopman, A. D. M.; Beulens, J. W.; Ridderstråle, M.; Hansen, T. H.; Allin, K. H.; Hansen, T.; Vestergaard, H.; Mari, A. (American Diabetes Association, 2021-07-07)
      Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N=2111) underwent 2h-75g OGTT at baseline and 48 months. HbA1c was also ...