Now showing items 1-4 of 4

    • Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores 

      Barnes, D. R.; Silvestri, V.; Leslie, G.; McGuffog, L.; Dennis, J.; Yang, X.; Adlard, J.; Agnarsson, B. A.; Ahmed, M.; Aittomäki, K.; Andrulis, I. L.; Arason, A.; Arnold, N.; Auber, B.; Azzollini, J.; Balmaña, J.; Barkardottir, R. B.; Barrowdale, D.; Barwell, J.; Belotti, M.; Benitez, J.; Berthet, P.; Boonen, S. E.; Borg, Å; Bozsik, A.; Brady, A.; Brennan, P.; Brewer, C.; Brunet, J.; Bucalo, A.; Buys, S. S.; Caldés, T.; Caligo, M. A.; Campbell, I.; Cassingham, H.; Lotte Christensen, L.; Cini, G.; Claes, K. B. M.; Cook, J.; Coppa, A.; Cortesi, L.; Damante, G.; Darder, E.; Davidson, R.; de la Hoya, M.; De Leeneer, K.; de Putter, R.; Del Valle, J.; Diez, O.; Chun Ding, Y.; Domchek, S. M.; Donaldson, A.; Eason, J.; Eeles, R.; Engel, C.; Gareth Evans, D.; Feliubadaló, L.; Fostira, F.; Frone, M.; Frost, D.; Gallagher, D.; Gehrig, A.; Giraud, S.; Glendon, G.; Godwin, A. K.; Goldgar, D. E.; Greene, M. H.; Gregory, H.; Gross, E.; Hahnen, E.; Hamann, U.; Hansen, T. V. O.; Hanson, H.; Hentschel, J.; Horvath, J.; Izatt, L.; Izquierdo, A.; James, P. A.; Janavicius, R.; Birk Jensen, U.; Johannsson, O. T.; John, E. M.; Kramer, G.; Kroeldrup, L.; Kruse, T. A.; Lautrup, C.; Lazaro, C.; Lesueur, F.; Lopez-Fernández, A.; Mai, P. L.; Manoukian, S.; Matrai, Z.; Matricardi, L.; Maxwell, K. N.; Mebirouk, N.; Meindl, A.; Montagna, M.; Monteiro, A. N.; Morrison, P. J.; Muranen, T. A.; Murray, A.; Nathanson, K. L.; Neuhausen, S. L.; Nevanlinna, H.; Nguyen-Dumont, T.; Niederacher, D.; Olah, E.; Olopade, O. I.; Palli, D.; Parsons, M. T.; Sokilde Pedersen, I.; Peissel, B.; Perez-Segura, P.; Peterlongo, P.; Petersen, A. H.; Pinto, P.; Porteous, M. E.; Pottinger, C.; Angel Pujana, M.; Radice, P.; Ramser, J.; Rantala, J.; Robson, M.; Rogers, M. T.; Rønlund, K.; Rump, A.; María Sánchez de Abajo, A.; Shah, P. D.; Sharif, S.; Side, L. E.; Singer, C. F.; Stadler, Z.; Steele, L.; Stoppa-Lyonnet, D.; Sutter, C.; Yen Tan, Y.; Teixeira, M. R.; Teulé, A.; Thull, D. L.; Tischkowitz, M.; Toland, A. E.; Tommasi, S.; Toss, A.; Trainer, A. H.; Tripathi, V.; Valentini, V.; van Asperen, C. J.; Venturelli, M.; Viel, A.; Vijai, J.; Walker, L.; Wang-Gohrke, S.; Wappenschmidt, B.; Whaite, A.; Zanna, I.; Offit, K.; Thomassen, M.; Couch, F. J.; Schmutzler, R. K.; Simard, J.; Easton, D. F.; Chenevix-Trench, G.; Antoniou, A. C.; Ottini, L. (Oxford University Press, 2021-07-28)
      BACKGROUND: Recent population-based female breast cancer and prostate cancer polygenic risk scores (PRS) have been developed. We assessed the associations of these PRS with breast and prostate cancer risks for male BRCA1 ...
    • Diagnosis of lethal or prenatal-onset autosomal recessive disorders by parental exome sequencing. 

      Stals, Karen; Wakeling, M. N.; Baptista, Júlia; Caswell, R.; Parrish, Andrew; Rankin, Julia; Tysoe, Carolyn; Jones, Garan; Gunning, Adam C; Lango-Allen, H.; Bradley, L.; Brady, A. F.; Carley, H.; Carmichael, J. A.; Castle, B.; Cilliers, D.; Cox, H.; Deshpande, C.; Dixit, A.; Eason, J.; Elmslie, F.; Fry, A. E.; Fryer, A.; Holder, M.; Homfray, T.; Kivuva, Emma; McKay, V.; Newbury-Ecob, R.; Parker, Michael; Savarirayan, Ravi; Searle, C.; Shannon, N.; Shears, D.; Smithson, S.; Thomas, E.; Turnpenny, Peter D.; Varghese, V.; Vasudevan, P.; Wakeling, E.; Baple, E. L.; Ellard, Sian (Wiley, 2017-11-02)
      Rare genetic disorders resulting in prenatal or neonatal death are genetically heterogeneous but testing is often limited by the availability of fetal DNA, leaving couples without a potential prenatal test for future ...
    • Effect of BRCA Mutations on Metastatic Relapse and Cause-specific Survival After Radical Treatment for Localised Prostate Cancer 

      Castro, E.; Goh, C.; Leongamornlert, D.; Saunders, E.; Tymrakiewicz, M.; Dadaev, T.; Govindasami, K.; Guy, M.; Ellis, S.; Frost, D.; Bancroft, E.; Cole, T.; Tischkowitz, M.; Kennedy, M. J.; Eason, J.; Brewer, Carole; Evans, D. G.; Davidson, R.; Eccles, D.; Porteous, M. E.; Douglas, F.; Adlard, J.; Donaldson, A.; Antoniou, A. C.; Kote-Jarai, Z.; Easton, D. F.; Olmos, D.; Eeles, R. (Elsevier, 2015-08-01)
      BACKGROUND: Germline BRCA mutations are associated with worse prostate cancer (PCa) outcomes; however, the most appropriate management for mutation carriers has not yet been investigated. OBJECTIVE: To evaluate the response ...
    • Lymphocyte telomere length is long in BRCA1 and BRCA2 mutation carriers regardless of cancer-affected status 

      Pooley, K. A.; McGuffog, L.; Barrowdale, D.; Frost, D.; Ellis, S. D.; Fineberg, E.; Platte, R.; Izatt, L.; Adlard, J.; Bardwell, J.; Brewer, Carole; Cole, T.; Cook, J.; Davidson, R.; Donaldson, A.; Dorkins, H.; Douglas, F.; Eason, J.; Houghton, C.; Kennedy, M. J.; McCann, E.; Miedzybrodzka, Z.; Murray, Anna; Porteous, M. E.; Rogers, M. T.; Side, L. E.; Tischkowitz, M.; Walker, L.; Hodgson, S.; Eccles, D. M.; Morrison, P. J.; Evans, D. G.; Eeles, R. A.; Antoniou, A. C.; Easton, D. F.; Dunning, A. M.; Embrace, (Cancer Epidemiol Biomarkers Prev, 2014-06-01)
      BACKGROUND: Telomere length has been linked to risk of common diseases, including cancer, and has previously been proposed as a biomarker for cancer risk. Germline BRCA1 and BRCA2 mutations predispose to breast, ovarian, ...