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    • In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism. 

      Salvatori, R.; Radian, S.; Diekmann, Y.; Iacovazzo, D.; David, A.; Gabrovska, P.; Grassi, G.; Bussell, Anna-Marie; Stals, Karen; Weber, A.; Quinton, R.; Crowne, E. C.; Corazzini, V.; Metherell, L.; Kearney, T.; Du Plessis, D.; Sinha, A. K.; Baborie, A.; Lecoq, A-L; Chanson, P.; Ansorge, O.; Ellard, Sian; Trainer, P. J.; Balding, D.; Thomas, M. G.; Korbonits, M. (BioScientifica, 2017-09)
      Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are associated with pituitary adenoma, acromegaly and gigantism. Identical alleles in unrelated pedigrees could be inherited from a common ancestor ...