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Now showing items 1-20 of 1795
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The 0.1% of the population with glucokinase monogenic diabetes can be recognized by clinical characteristics in pregnancy: the Atlantic Diabetes in Pregnancy cohort.
Chakera, Ali J.; Spyer, G.; Vincent, N.; Ellard, Sian; Hattersley, Andrew T.; Dunne, F. P. (American Diabetes Association, 2014-02)Identifying glucokinase monogenic diabetes (GCK-MODY) in pregnancy is important, as management is different from management for other forms of gestational diabetes mellitus (GDM) and there is no increased maternal risk of ... -
1-year outcomes of the Xen45 glaucoma implant.
Smith, Michael; Charles, Roselin; Byles, Daniel (Nature, 2018-12-14)To describe the 12-month outcomes of the Xen45 glaucoma stent. -
10 Years of Improving Pain Assessment Documentation in a Foundation Trust Hospital
Murdoch, Julie; Price, Lucy; Cook, Laura; Wassall, Richard; Jackson, Mark (2016-09) -
18F-FDG PET in the Diagnosis of Vascular Prosthetic Graft Infection: A Diagnostic Test Accuracy Meta-Analysis.
Rojoa, D.; Kontopodis, N.; Antoniou, Stavros A.; Ioannou, C. V.; Antoniou, G. A. (Elsevier, 2018-09-18)For the diagnosis of vascular prosthetic graft infection (VPGI), an intra-operative peri-graft biopsy is often required. Controversy exists regarding the use of imaging techniques in the diagnostic process. This study aimed ... -
2014 European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children
Lazarus, J.; Brown, R. S.; Daumerie, C.; Hubalewska-Dydejczyk, A.; Negro, R.; Vaidya, Bijay (Karger, 2014-06-01)This guideline has been produced as the official statement of the European Thyroid Association guideline committee. Subclinical hypothyroidism (SCH) in pregnancy is defined as a thyroid-stimulating hormone (TSH) level above ... -
27 years of prenatal diagnosis for Huntington disease in the United Kingdom.
Turnpenny, Peter D. (Nature, 2018-12-14)There is little long-term, population-based data on uptake of prenatal diagnosis for Huntington disease (HD), a late-onset autosomal dominant neurodegenerative disorder, and the effect of the availability of preimplantation ... -
3-phase Technicium-99m bone scanning in patients with pain in the hip region after cemented total hip replacement: a multicentre series of 100 cases.
Hill, Daniel S; Naim, Soulat; Powell, Roy; Kinsella, Denis; Toms, Andrew; Howell, Jonathan (Wichtig, 2017-11-21)The aim of this study was to assess the benefit of a Technetium-99M (HDP) 3-phase bone scan (TPBS) as an additional diagnostic test in the evaluation of pain in the hip region following cemented total hip replacement (THR) ... -
5-hydroxymethylcytosine is highly dynamic across human fetal brain development.
Spiers, H.; Hannon, E.; Schalkwyk, L. C.; Bray, N. J.; Mill, Jonathan (BioMed Central, 2017-09-18)Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during ... -
A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - comment.
Charman, Carolyn (Wiley, 2017-10) -
A 60 year history of recurrent hypoglycaemia
Foteinopoulou, E.; Colclough, Kevin; Strachan, M. (BioScientifica, 2018-04-09) -
8b.07: Results from the Uk Renal Denervation Affiliation- 246 Cases from 17 Centres
Sharp, Andrew; Hameed, A.; Nightingale, A.; Martin, U.; Mark, P.; McKane, W.; Cunnington, M.; Lobo, M.; Mahadevan, K.; Richardson, T.; Gerber, R.; ClifFord, Pete; Burchell, A.; Doulton, T.; Dimario, C.; Thackray, S.; Redwood, S.; Davies, J.; Antonios, T.; Dasgupta, I. (Wolters Kluwer, 2015-06)OBJECTIVE: To describe the UK experience with Renal Denervation (RDN). DESIGN AND METHOD: RDN may lower blood pressure (BP) in people with resistant hypertension.The UK Renal Denervation Affiliation is an independent, ... -
Abdominoperineal Excision: A Confusion in Terminology.
White, E S; Smart, Neil J.; Daniels, Ian R. (Wolters Kluwer, 2015-07) -
Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.
Patmanathan, S. N.; Johnson, Steven P.; Lai, Sook L.; Panja Bernam, S.; Lopes, V.; Wei, W.; Ibrahim, M. H.; Torta, F.; Narayanaswamy, P.; Wenk, M. R.; Herr, D. R.; Murray, P. G.; Yap, L. F.; Paterson, I. C. (Nature, 2016-05-10)Oral squamous cell carcinoma (OSCC) is a lethal disease with a 5-year mortality rate of around 50%. Molecular targeted therapies are not in routine use and novel therapeutic targets are required. Our previous microarray ... -
Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy.
James, N D; de Bono, J S; Spears, M R; Clarke, NW; Mason, M D; Dearnaley, D P; Ritchie, A W S; Amos, C L; Gilson, C; Jones, R J; Matheson, D; Millman, R; Attard, G; Chowdhury, S; Cross, W R; Gillessen, S; Parker, C C; Russell, J M; Berthold, D R; Brawley, C; Adab, F; Aung, San; Birtle, A J; Bowen, J; Brock, S; Chakraborti, P; Ferguson, C; Gale, J; Gray, E; Hingorani, M; Hoskin, P J; Lester, J F; Malik, Z I; McKinna, F; McPhail, N; Money-Kyrle, J; O'Sullivan, J; Parikh, O; Protheroe, A; Robinson, A; Srihari, N N; Thomas, C; Wagstaff, J; Wylie, J; Zarkar, A; Parmar, M K B; Sydes, M R (New England Journal of Medicine, 2017-07)Abiraterone acetate plus prednisolone improves survival in men with relapsed prostate cancer. We assessed the effect of this combination in men starting long-term androgen-deprivation therapy (ADT), using a multigroup, ... -
Abnormal splicing of hepatocyte nuclear factor 1 alpha in maturity-onset diabetes of the young.
Bulman, M. P.; Harries, L. W.; Hansen, T.; Shepherd, Maggie; Kelly, W. F.; Hattersley, Andrew T.; Ellard, Sian (Springer, 2002-10)Mutations in the HNF-1 alpha gene result in maturity-onset diabetes of the young (MODY); an early-onset, dominantly inherited form of diabetes caused by pancreatic beta-cell dysfunction. Splice site mutations represent ... -
Abobotulinumtoxin A In The Management of Cervical Dystonia In The United Kingdom: A Cost-Effectiveness Analysis
Desai, K.; Muthukumar, M.; Abogunrin, S.; Harrower, Timothy; Dinet, J.; Gabriel, S. (Elsevier, 2015-11-01) -
AbobotulinumtoxinA in the management of cervical dystonia in the United Kingdom: a budget impact analysis
Abogunrin, S.; Brand, S.; Desai, K.; Dinet, J.; Gabriel, S.; Harrower, Timothy (Dove Press, 2015-09-09)BACKGROUND: Cervical dystonia (CD) can be effectively managed by a combination of botulinum neurotoxin A (BoNT-A) and conventional therapy (skeletal muscle relaxants and rehabilitative therapy), but the costs of different ... -
Absence of Epstein-Barr virus infection in squamous cell carcinoma of upper urinary tract and urinary bladder
Ng, K-F; Chuang, C-K; Chang, P-L; Chu, S-H; Wallace, Christopher G; Chen, T-C (Elsevier, 2006-10)To address whether Epstein-Barr virus (EBV) infection may be involved in the carcinogenesis of squamous cell carcinoma of the upper urinary tract and urinary bladder (SCC-UB). EBV has been implicated in the genesis of a ... -
Abstract 150: Complications and Outcomes of Thrombolysis in Stroke Patients Aged 90 and Over: UK National Registry Data
Paley, L; Bray, B. D.; James, Martin; Tyrrell, P. J.; Behrouz, R; Smith, C. J.; Di Napoli, M.; Cloud, G. C.; Rudd, A. (American Stroke Association, 2016-02) -
Abstract 152: Complications and Outcomes From Thrombolysis in Stroke Patients With Significant Pre-stroke Disability: Data From the UK National Stroke Registry
Paley, L; Bray, B. D.; James, Martin; Tyrrell, P. J.; Hoffman, A.; Cloud, G. C.; Rudd, A. (American Stroke Association, 2016-02)