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Now showing items 21-40 of 3408
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5-hydroxymethylcytosine is highly dynamic across human fetal brain development.
(BioMed Central, 2017-09-18)Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during ... -
50 years of total knee arthroplasty
(British Editorial Society of Bone & Joint Surgery, 2019-05) -
52 I’m on the Floor and Can’t Get up and it’s Really Annoying: A Qualitative Investigation of Patient and Staff Perceptions of Options for Getting up From the Floor Following A Fall
(Oxford University Press, 2021-03-01)Falls are the most common reason for ambulance call-outs resulting in non-conveyance. Even in the absence of injury, only half of those who have fallen can get themselves up off the floor. Many remain there for over an ... -
A 60 year history of recurrent hypoglycaemia
(BioScientifica, 2018-04-09) -
811 DELIRIUM IN COVID-19: COMMON AND CLINICALLY SIGNIFICANT: EXPERIENCES FROM THE NIGHTINGALE HOSPITAL EXETER
(Oxford University Press, 2022-03-08)Delirium is an independent predictor of mortality in patients admitted with community-acquired pneumonia (Pieralli, 2014), but significance and incidence in Covid-19 infection has not been established. The Nightingale ... -
8b.07: Results from the Uk Renal Denervation Affiliation- 246 Cases from 17 Centres
(Wolters Kluwer, 2015-06)OBJECTIVE: To describe the UK experience with Renal Denervation (RDN). DESIGN AND METHOD: RDN may lower blood pressure (BP) in people with resistant hypertension.The UK Renal Denervation Affiliation is an independent, ... -
A 2021 consensus statement on osteotomies around the knee by the UK Knee Osteotomy consensus Group (KOG)
(Elsevier, 2021-09-22)BACKGROUND: There are significant deficiencies in the evidence base of modern-day osteotomy which result in significant variation in practice between surgeons. The purpose of this statement was to develop a consensus ... -
A biallelic SNIP1 Amish founder variant causes a recognizable neurodevelopmental disorder
(PLoS One, 2021-09-01)SNIP1 (Smad nuclear interacting protein 1) is a widely expressed transcriptional suppressor of the TGF-β signal-transduction pathway which plays a key role in human spliceosome function. Here, we describe extensive genetic ... -
A case of avian influenza A(H5N1) in England, January 2022
(Unknown, 2022-02-01)On 5 January 2022, high pathogenicity avian influenza A(H5N1) was confirmed in an individual who kept a large flock of ducks at their home in England. The individual remained asymptomatic. H5N1 was confirmed in 19/20 sampled ... -
A comparative study of treadmill tests and heel raising exercise for peripheral arterial disease
(Elsevier, 1997-03-01)OBJECTIVES: This two part study validated a 1 min treadmill exercise test and compared this with simple heel raising exercise. METHODS: In an initial study of 24 claudicants (aged 43-79, median 63 years), ankle pressures ... -
A comparison of surgical practice and operative outcomes between retroperitoneal and transperitoneal laparoscopic nephrectomies – 6 years of data from the BAUS Nephrectomy database
Objectives:While the choice of surgical approach for laparoscopic nephrectomy is broadly split between transperitoneal and retroperitoneal options, the evidence for the impact of this decision on perioperative outcomes is ... -
A comprehensive high cost drugs dataset from the NHS in England - An OpenSAFELY-TPP Short Data Report
(Wellcome, 2022-06-01)Background: At the outset of the COVID-19 pandemic, there was no routine comprehensive hospital medicines data from the UK available to researchers. These records can be important for many analyses including the effect of ... -
A cost consequence study of the impact of a dermatology-trained practice nurse on the quality of life of primary care patients with eczema and psoriasis
(Royal College of General Practitioners, 2000-08-24)BACKGROUND: The practice nurse is central to the development of a primary care-led National Health Service. Skin diseases can have a major impact on patients' lives but general practitioners (GPs) lack many of the skills ... -
A dosimetric study to improve the quality of nodal radiotherapy in breast cancer
(British Institute of Radiology, 2021-08-13)OBJECTIVES: Field-based planning for regional nodal breast radiotherapy (RT) used to be standard practice. This study evaluated a field-based posterior axillary boost (PAB) and two forward-planned intensity-modulated RT ... -
A feasibility study of multisite networked digital pathology reporting in England
(Medknow Publications, 2022-01-01)<b>Background:</b> The objective of the project was to evaluate the feasibility of introducing a single-networked digital histopathology reporting platform in the Southwest Peninsula region of England by allowing pathologists ... -
A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor
(PLoS One, 2021-06-10)Frozen shoulder is a painful condition that often requires surgery and affects up to 5% of individuals aged 40–60 years. Little is known about the causes of the condition, but diabetes is a strong risk factor. To begin to ... -
A hemizygous mutation in the FOXP3 gene (IPEX syndrome) resulting in recurrent X-linked fetal hydrops: a case report
(Springer, 2021-02-26)Fetal hydrops is excessive extravasation of fluid into the third space in a fetus, which could be due to a wide differential of underlying pathology. IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) ...