Browsing by Title

Tape to view: novel technique to improve axillary access

Dalal, A; Ives, Christine (Royal College of Surgeons of England, 2019-11)

Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis

Gibbons, Michael A. (HighWire, 2021-05-27)

Galectin (Gal)-3 is a profibrotic β-galactoside-binding lectin that plays a key role in the pathogenesis of idiopathic pulmonary fibrosis (IPF) and IPF exacerbations. TD139 is a novel and potent small-molecule inhibitor ...

Targeted prostate cancer screening in BRCA1 and BRCA2 mutation carriers: results from the initial screening round of the IMPACT study

Bancroft, E. K.; Page, E. C.; Castro, E.; Lilja, H.; Vickers, A.; Sjoberg, D.; Assel, M.; Foster, C. S.; Mitchell, G.; Drew, K.; Maehle, L.; Johannsson, O.; Khoo, V.; Kote-Jarai, Z.; Lubinski, J.; Axcrona, U.; Melia, J.; McKinley, J.; Mitra, A. V.; Moynihan, C.; Rennert, G.; Axcrona, K.; Suri, M.; Wilson, P.; Killick, E.; Impact Collaborators; Moss, S.; Eeles, R. A.; Evans, D. G.; Bulman, B.; Eccles, D.; McBride, D.; van Asperen, C.; Vasen, H.; Kiemeney, L. A.; Ringelberg, J.; Cybulski, C.; Wokolorczyk, D.; Selkirk, C.; Hulick, P. J.; Bojesen, A.; Skytte, A. B.; Lam, J.; Taylor, L.; Oldenburg, R.; Cremers, R.; Verhaegh, G.; van Zelst-Stams, W. A.; Oosterwijk, J. C.; Blanco, I.; Salinas, M.; Cook, J.; Rosario, D. J.; Buys, S.; Conner, T.; Ausems, M. G.; Ong, K. R.; Hoffman, J.; Domchek, S.; Powers, J.; Teixeira, M. R.; Maia, S.; Foulkes, W. D.; Taherian, N.; Ruijs, M.; Helderman-van den Enden, A. T.; Izatt, L.; Davidson, R.; Adank, M. A.; Walker, L.; Schmutzler, R.; Tucker, K.; Kirk, J.; Hodgson, S.; Harris, M.; Douglas, F.; Lindeman, G. J.; Zgajnar, J.; Tischkowitz, M.; Clowes, V. E.; Susman, R.; Ramon y Cajal, T.; Patcher, N.; Gadea, N.; Spigelman, A.; van Os, T.; Liljegren, A.; Side, L.; Brewer, Carole; Brady, A. F.; Donaldson, A.; Stefansdottir, V.; Friedman, E.; Chen-Shtoyerman, R.; Amor, D. J.; Copakova, L.; Barwell, J.; Giri, V. N.; Murthy, V.; Nicolai, N.; Teo, S. H.; Greenhalgh, L.; Strom, S.; Henderson, A.; McGrath, John S; Gallagher, D.; Aaronson, N.; Ardern-Jones, Angus; Bangma, C.; Dearnaley, D.; Costello, P.; Eyfjord, J.; Rothwell, J.; Falconer, A.; Gronberg, H.; Hamdy, F. C. (Elsevier, 2014-09-01)

BACKGROUND: Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) than noncarriers. IMPACT (Identification of ...

Targeting surface voids to counter membrane disorders in lipointoxication-related diseases.

Ferru-Clément, R.; Spanova, M.; Dhayal, S.; Morgan, Noel; Hélye, R.; Becq, F.; Hirose, H.; Antonny, B.; Vamparys, L.; Fuchs, P. F. J.; Ferreira, T. (The Company of Biologists, 2016-06-15)

Saturated fatty acids (SFA), which are abundant in the so-called western diet, have been shown to efficiently incorporate within membrane phospholipids and therefore impact on organelle integrity and function in many cell ...

The Tatton-Brown-Rahman Syndrome: A clinical study of 55 individuals with de novo constitutive DNMT3A variants

Tatton-Brown, K.[et al]; Turnpenny, Peter D. (Wellcome, 2018-04)

Tatton-Brown-Rahman syndrome (TBRS; OMIM 615879), also known as the DNMT3A-overgrowth syndrome, is an overgrowth intellectual disability syndrome first described in 2014 with a report of 13 individuals with constitutive ...

Teaching classroom management ? a potential public health intervention?

Marlow, R.; Hansford, L.; Edwards, V.; Ukoumunne, O. C.; Norman, S.; Ingarfield, S.; Sharkey, S.; Logan, Stuart; Ford, T. J. (Emerald, 2015-06)

The purpose of this paper is to explore the feasibility of a classroom management course as a public health intervention. Improved socio-emotional skills may boost children’s developmental and academic trajectory, while ...

A technique to visualise the urethral meatus in difficult male catheterisations.

Khadhouri, Sinan; Crundwell, Malcolm (Royal College of Surgeons, 2015-12-16)

Teledermatology using National Health Service e-Referral: streamlining patient pathways (BT04)

Charman, Carolyn; Al-Nuaimi, Yusur (Wiley, 2016-07-04)

Telephone clinics for follow-up in hand surgery: an effective model after COVID-19?

Hendrickson, SA; Witt, P; Watts, A (Royal College of Surgeons, 2021-07-01)

IntroductionTelephone clinics were adopted for follow-up appointments in our plastic hand surgery department during the COVID-19 pandemic. They may pose advantages in cost, efficiency and environmental impact compared wi ...

Telephone Interview for Cognitive Status Scores Associate with Cognitive Impairment and Alzheimer's Disease Pathology at Death

Robinson, A. C.; Davidson, Y. S.; Roncaroli, F.; Minshull, J.; Tinkler, P.; Cairns, M.; Horan, M. A.; Payton, A.; Mann, D. M. A. (IOS Press, 2021-11-09)

BACKGROUND: Early diagnosis of Alzheimer's disease (AD) provides an opportunity for early intervention. Cognitive testing has proven to be a reliable way to identify individuals who may be at risk of AD. The Telephone ...

Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants

Pilling, L. C.; Melzer, David (Wiley, 2019-12)

Inherited genetic variation influencing leukocyte telomere length provides a natural experiment for testing associations with health outcomes, more robust to confounding and reverse causation than observational studies. ...

Telomere length and risk of idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease: a mendelian randomisation study

Duckworth, Anna; Gibbons, Michael A.; Beaumont, Robin N.; Wood, A. R.; Lunnon, Katie; Tyrrell, Jessica; Scotton, C. J. (Elsevier Science, 2021-03)

Background: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease accounting for 1% of UK deaths. In the familial form of pulmonary fibrosis, causal genes have been identified in about 30% of cases, and a majority ...

Temperature Spatially Offset Raman Spectroscopy (T-SORS): Subsurface Chemically Specific Measurement of Temperature in Turbid Media Using Anti-Stokes Spatially Offset Raman Spectroscopy.

Gardner, B.; Matousek, P.; Stone, Nick (American Chemical Society, 2016-01-05)

Here we propose and demonstrate a new analytical method for the noninvasive measurement of subsurface temperatures within diffusely scattering (turbid) media in combination with high chemical selectivity. The method is ...

Temporal Relationship Between Depressive Symptoms and Cognition in Mid and Late Life: A Longitudinal Cohort Study

Corbett, Anne; Ballard, Clive (Elsevier Science, 2020-08)

Objectives: To examine the bidirectional temporal relationship between depressive symptoms and cognition in relation to risk, reaction, and prodrome. Design: Cross-lag analysis of longitudinal data collected online at ...

Ten years of the national genetic diabetes nurse network: a model for the translation of genetic information into clinical care

Shepherd, Maggie; Colclough, Kevin; Ellard, Sian; Hattersley, Andrew T. (Clinical Medicine, 2014-04-01)

Increasing technological advances have resulted in the recognition of a range of genetic conditions not traditionally seen by clinical genetics teams. This has implications for the education of other healthcare professionals ...

Ten-year results for a single-surgeon series of Scorpio non-restrictive geometry (NRG) posterior stabilised (PS) total knee replacement

Bajada, Stefan; Searle, David; Toms, Andrew D. (Springer, 2019-05)

To report the long-term results for a single-surgeon consecutive series of Scorpio non-restrictive geometry (NRG) posterior stabilised (PS) total knee replacement (TKR).