Browsing by Title
Now showing items 1393-1412 of 1824
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Quality control and conduct of genome-wide association meta-analyses.
(Nature Protocols, 2014-05)Rigorous organization and quality control (QC) are necessary to facilitate successful genome-wide association meta-analyses (GWAMAs) of statistics aggregated across multiple genome-wide association studies. This protocol ... -
The quality of intensive care unit nurse handover related to end of life: a descriptive comparative international study
(Elsevier, 2015-01-01)BACKGROUND: Quality ICU end-of-life-care has been found to be related to good communication. Handover is one form of communication that can be problematic due to lost or omitted information. A first step in improving care ... -
Quality of life in thyroid eye disease: impact of quality of care.
(BioScientifica, 2011-05)Thyroid eye disease (TED) is a chronic debilitating condition causing physical discomfort, facial disfigurement and impaired visual function. The physical consequences of TED could have a negative and lasting impact on ... -
Quality of placental RNA: Effects of explant size and culture duration.
(Elsevier, 2016-10)We evaluated the impact of placental micro (≤50 mg) and macro (∼200 mg) explants, oxygen concentration and culture method on placental RNA quality after long-term culture. Our findings show that micro explants cultured at ... -
Quantifying the contribution of recessive coding variation to developmental disorders.
(Science, 2018-11-08)We estimated the genome-wide contribution of recessive coding variation from 6,040 families from the Deciphering Developmental Disorders study. The proportion of cases attributable to recessive coding variants was 3.6% in ... -
Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.
(BioMed Central, 2017-01-23)Endoplasmic reticulum (ER) stress is a hallmark of neurodegenerative diseases such as multiple sclerosis (MS). However, this physiological mechanism has multiple manifestations that range from impaired clearance of unfolded ... -
Radiofrequency-induced Thermo-chemotherapy Effect Versus a Second Course of Bacillus Calmette-Guérin or Institutional Standard in Patients with Recurrence of Non-muscle-invasive Bladder Cancer Following Induction or Maintenance Bacillus Calmette-Guérin Therapy (HYMN): A Phase III, Open-label, Randomised Controlled Trial.
(Elsevier, 2018-09-28)There is no effective intravesical second-line therapy for non-muscle-invasive bladder cancer (NMIBC) when bacillus Calmette-Guérin (BCG) fails. -
The radiological diagnosis of frontotemporal dementia in everyday practice: an audit of reports, review of diagnostic criteria, and proposal for service improvement.
(Elsevier, 2016-01)To investigate how commonly valuable diagnostic information regarding the frontotemporal dementias (FTDs) may be missed on routine radiological reporting. -
Radiological progression of end colostomy trephine diameter and area
(BJS, 2018-10-24)Development of a parastomal hernia is common following abdominoperineal excision (APE). The true incidence is difficult to assess fully owing to differing lengths of follow-up and techniques used to assess herniation; ... -
Radiolucent triangle and U-bolster for lower leg positioning for circular frame application.
(Royal College of Surgeons, 2018-08-16) -
Radiotherapy for acute, high-grade spinal cord compression caused by vertebral haemangioma
(Elsevier, 2015-10-19) -
Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial.
(Elsevier, 2018-10-18)Based on previous findings, we hypothesised that radiotherapy to the prostate would improve overall survival in men with metastatic prostate cancer, and that the benefit would be greatest in patients with a low metastatic ... -
Raising awareness of Graves' orbitopathy with early warning cards.
(Wiley, 2017-07-29)Clinically significant Graves' orbitopathy (GO) develops in about 25% of those with Graves' disease (GD); most cases of GD in the UK are managed by endocrinologists. Despite this, patients report significant delays before ... -
Raman spectroscopy and multivariate analysis for the non invasive diagnosis of clinically inconclusive vulval lichen sclerosus.
(Royal Society of Chemistry, 2016-11-09)Vulval lichen sclerosus (LS) is a common inflammatory condition associated with an increased risk of developing vulval carcinoma. Diagnosis is usually clinical although biopsy is necessary if the diagnosis is uncertain or ... -
Random non-fasting C-peptide testing can identify patients with insulin-treated type 2 diabetes at high risk of hypoglycaemia.
(Springer, 2017-10-05)The aim of this study was to determine whether random non-fasting C-peptide (rCP) measurement can be used to assess hypoglycaemia risk in insulin-treated type 2 diabetes. -
Random non-fasting C-peptide: bringing robust assessment of endogenous insulin secretion to the clinic.
(Wiley, 2016-04-21)Measuring endogenous insulin secretion using C-peptide can assist diabetes management, but standard stimulation tests are impractical for clinical use. Random non-fasting C-peptide assessment would allow testing when a ... -
Randomised controlled trial of the Limit of Detection of Troponin and ECG Discharge (LoDED) strategy versus usual care in adult patients with chest pain attending the emergency department: study protocol.
(BMJ, 2018-10-02)Observational data suggest a single high-sensitivity troponin blood test taken at emergency department (ED) presentation could be used to rule out major adverse cardiac events (MACE) in 10%-60% of ED patients with chest ... -
Randomised Evaluation of Modified Valsalva Effectiveness in Re-Entrant Tachycardias (REVERT)
(2015-11-05)The Valsalva manoeuvre is an internationally recommended physical emergency treatment for supraventricular tachycardia (SVT), an abnormal fast heart rhythm. However in normal practice, the manoeuvre only works in 5–20% of ...