Browsing by Title
Now showing items 2020-2039 of 2646
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Quality control and conduct of genome-wide association meta-analyses.
(Nature Protocols, 2014-05)Rigorous organization and quality control (QC) are necessary to facilitate successful genome-wide association meta-analyses (GWAMAs) of statistics aggregated across multiple genome-wide association studies. This protocol ... -
Quality improvement project identifies factors associated with delay in IBD diagnosis
(Wiley, 2020-08)Background: Delay in the diagnosis of inflammatory bowel disease (IBD) is common and contemporary UK studies are lacking. Aim: To determine factors associated with, and the consequences of, a prolonged time to diagnosis ... -
The quality of intensive care unit nurse handover related to end of life: a descriptive comparative international study
(Elsevier, 2015-01-01)BACKGROUND: Quality ICU end-of-life-care has been found to be related to good communication. Handover is one form of communication that can be problematic due to lost or omitted information. A first step in improving care ... -
Quality of life in thyroid eye disease: impact of quality of care.
(BioScientifica, 2011-05)Thyroid eye disease (TED) is a chronic debilitating condition causing physical discomfort, facial disfigurement and impaired visual function. The physical consequences of TED could have a negative and lasting impact on ... -
Quality of placental RNA: Effects of explant size and culture duration.
(Elsevier, 2016-10)We evaluated the impact of placental micro (≤50 mg) and macro (∼200 mg) explants, oxygen concentration and culture method on placental RNA quality after long-term culture. Our findings show that micro explants cultured at ... -
Quantification of the overall contribution of gene-environment interaction for obesity-related traits
(Nature Publishing Group, 2020-03-13)The growing sample size of genome-wide association studies has facilitated the discovery of gene-environment interactions (GxE). Here we propose a maximum likelihood method to estimate the contribution of GxE to continuous ... -
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm
(eLife Sciences Publications Ltd., 2020-05-05)Biological aging is the gradual, progressive decline in system integrity that occurs with advancing chronological age, causing morbidity and disability. Measurements of the pace of aging are needed as surrogate endpoints ... -
Quantification of Thigh Muscle Volume in Children and Adolescents Using Magnetic Resonance Imaging
(Taylor & Francis, 2020-01-12)Estimating muscle volume (MV) using variable numbers of cross-sectional area (CSA) slices obtained from magnetic resonance imaging (MRI) introduces an error that is known in adults, but not in children and adolescents, ... -
Quantifying the contribution of recessive coding variation to developmental disorders.
(Science, 2018-11-08)We estimated the genome-wide contribution of recessive coding variation from 6,040 families from the Deciphering Developmental Disorders study. The proportion of cases attributable to recessive coding variants was 3.6% in ... -
A quantitative LC-MS/MS method for analysis of mitochondrial -specific oxysterol metabolism
(Elsevier Science, 2020-09)Oxysterols are critical regulators of inflammation and cholesterol metabolism in cells. They are oxidation products of cholesterol and may be differentially metabolised in subcellular compartments and in biological fluids. ... -
Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.
(BioMed Central, 2017-01-23)Endoplasmic reticulum (ER) stress is a hallmark of neurodegenerative diseases such as multiple sclerosis (MS). However, this physiological mechanism has multiple manifestations that range from impaired clearance of unfolded ... -
Radiofrequency-induced Thermo-chemotherapy Effect Versus a Second Course of Bacillus Calmette-Guérin or Institutional Standard in Patients with Recurrence of Non-muscle-invasive Bladder Cancer Following Induction or Maintenance Bacillus Calmette-Guérin Therapy (HYMN): A Phase III, Open-label, Randomised Controlled Trial.
(Elsevier, 2018-09-28)There is no effective intravesical second-line therapy for non-muscle-invasive bladder cancer (NMIBC) when bacillus Calmette-Guérin (BCG) fails. -
The radiological diagnosis of frontotemporal dementia in everyday practice: an audit of reports, review of diagnostic criteria, and proposal for service improvement.
(Elsevier, 2016-01)To investigate how commonly valuable diagnostic information regarding the frontotemporal dementias (FTDs) may be missed on routine radiological reporting. -
Radiological progression of end colostomy trephine diameter and area
(BJS, 2018-10-24)Development of a parastomal hernia is common following abdominoperineal excision (APE). The true incidence is difficult to assess fully owing to differing lengths of follow-up and techniques used to assess herniation; ... -
Radiolucent triangle and U-bolster for lower leg positioning for circular frame application.
(Royal College of Surgeons, 2018-08-16) -
Radiotherapy for acute, high-grade spinal cord compression caused by vertebral haemangioma
(Elsevier, 2015-10-19) -
Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial.
(Elsevier, 2018-10-18)Based on previous findings, we hypothesised that radiotherapy to the prostate would improve overall survival in men with metastatic prostate cancer, and that the benefit would be greatest in patients with a low metastatic ... -
Raising awareness of Graves' orbitopathy with early warning cards.
(Wiley, 2017-07-29)Clinically significant Graves' orbitopathy (GO) develops in about 25% of those with Graves' disease (GD); most cases of GD in the UK are managed by endocrinologists. Despite this, patients report significant delays before ...