Browsing by Title
Now showing items 1393-1412 of 2543
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Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits
(Public Library of Science, 2020-08-14)Genetic studies have recently highlighted the importance of fat distribution, as well as overall adiposity, in the pathogenesis of obesity-associated diseases. Using a large study (n = 1,288) from 4 independent cohorts, ... -
Machine Learning in Aging Research
(Silverchair Information Systems, 2019-11-13) -
MAFA missense mutation causes familial insulinomatosis and diabetes mellitus.
(Proceedings of the National Academy of Sciences of the USA, 2018-01-30)The β-cell-enriched MAFA transcription factor plays a central role in regulating glucose-stimulated insulin secretion while also demonstrating oncogenic transformation potential in vitro. No disease-causing MAFA variants ... -
The magnetic resonance imaging appearance of the anterolateral ligament of the knee in association with anterior cruciate rupture.
(Springer, 2017-04-21)The magnetic resonance imaging (MRI) appearance of the anterolateral ligament (ALL) has been described. However, the appearance of this structure and injury, in the presence of anterior cruciate ligament (ACL) injury, is ... -
Magnetically controlled growing rods in the treatment of early-onset scoliosis: a note of caution.
(British Editorial Society of Bone and Joint Journal, 2017-06)The MAGnetic Expansion Control (MAGEC) system is used increasingly in the management of early-onset scoliosis. Good results have been published, but there have been recent reports identifying implant failures that may be ... -
Maintaining ear aesthetics in helical rim reconstruction
(Wolters Kluwer, 2014-03-01)BACKGROUND: Wedge resections of the helical rim may result in a significant deformity of the ear with the ear not only smaller but cupped and prominent too. Our technique involves resection of the wedge in the scaphal area ... -
Major surgery induces acute changes in measured DNA methylation associated with immune response pathways
(Nature Publishing Group, 2020-04-01)Surgery is an invasive procedure evoking acute inflammatory and immune responses that can influence risk for postoperative complications including cognitive dysfunction and delirium. Although the specific mechanisms driving ... -
The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells.
(Springer, 2014-01)Classically, type 1 diabetes is thought to proceed to absolute insulin deficiency. Recently developed ultrasensitive assays capable of detecting C-peptide under 5 pmol/l now allow very low levels of C-peptide to be detected ... -
Making connections: Social identification with new treatment groups for lifestyle management of severe obesity
(Wiley, 2020-04-08)Groups are regularly used to deliver healthcare services, including the management of obesity, and there is growing evidence that patients' experiences of such groups fundamentally shape treatment effects. This study ... -
Malignant melanoma: Claims and controversies
(Sage, 2018-08-13) -
A man with paraesthesia, headache, and vertigo.
(BMJ, 2017-11-23) -
Management of acute periprosthetic joint infection of the knee - Algorithms for the on call surgeon.
(Elsevier, 2016-06-23)Periprosthetic joint infection (PJI) remains a serious complication following a total knee replacement. Infections rates following arthroplasty range from 0.5% to 3%. The acutely infected knee replacement often presents ... -
Management of Behavioral and Psychological Symptoms in People With Alzheimer's Disease: An International Delphi Consensus
(Cambridge University Press, 2019-01)Behavioral and psychological symptoms of dementia (BPSD) are nearly universal in dementia, a condition occurring in more than 40 million people worldwide. BPSD present a considerable treatment challenge for prescribers and ... -
Management of children with type 1 diabetes during illness: a national survey.
(BMJ, 2016-02-22)Adequate sick-day management at home can reduce the risk of progression to diabetic ketoacidosis and admission to hospital. The aim of this project was to review the management of diabetes during illness. -
Management of common infections in pregnancy
(Sage, 2016-03-09)Pregnant women are peculiarly vulnerable to infections – the mechanism for this is multi-factorial and includes immune tolerance to the fetus (and placenta) itself, and maternal physiological changes, such as urinary stasis ... -
Management of extensive intraparotid vascular malformation: a case report
(Wolters Kluwer, 2014-06) -
Management of hypothyroidism in pregnancy: we must do better.
(Wiley, 2013-03) -
Management of paediatric hernia.
(BMJ, 2017-10-19) -
Management of patients in a combined thyroid eye clinic in secondary care
(Springer, 2014-02-01)The European Group on Graves' Orbitopathy (EUGOGO) recommends the use of specialised multidisciplinary clinics for the management of thyroid eye disease (TED). In the UK, many patients with TED are managed outside of ...