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Now showing items 1008-1027 of 1824
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MAFA missense mutation causes familial insulinomatosis and diabetes mellitus.
(Proceedings of the National Academy of Sciences of the USA, 2018-01-30)The β-cell-enriched MAFA transcription factor plays a central role in regulating glucose-stimulated insulin secretion while also demonstrating oncogenic transformation potential in vitro. No disease-causing MAFA variants ... -
The magnetic resonance imaging appearance of the anterolateral ligament of the knee in association with anterior cruciate rupture.
(Springer, 2017-04-21)The magnetic resonance imaging (MRI) appearance of the anterolateral ligament (ALL) has been described. However, the appearance of this structure and injury, in the presence of anterior cruciate ligament (ACL) injury, is ... -
Magnetically controlled growing rods in the treatment of early-onset scoliosis: a note of caution.
(British Editorial Society of Bone and Joint Journal, 2017-06)The MAGnetic Expansion Control (MAGEC) system is used increasingly in the management of early-onset scoliosis. Good results have been published, but there have been recent reports identifying implant failures that may be ... -
Maintaining ear aesthetics in helical rim reconstruction
(Wolters Kluwer, 2014-03-01)BACKGROUND: Wedge resections of the helical rim may result in a significant deformity of the ear with the ear not only smaller but cupped and prominent too. Our technique involves resection of the wedge in the scaphal area ... -
The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells.
(Springer, 2014-01)Classically, type 1 diabetes is thought to proceed to absolute insulin deficiency. Recently developed ultrasensitive assays capable of detecting C-peptide under 5 pmol/l now allow very low levels of C-peptide to be detected ... -
Malignant melanoma: Claims and controversies
(Sage, 2018-08-13) -
A man with paraesthesia, headache, and vertigo.
(BMJ, 2017-11-23) -
Management of acute periprosthetic joint infection of the knee - Algorithms for the on call surgeon.
(Elsevier, 2016-06-23)Periprosthetic joint infection (PJI) remains a serious complication following a total knee replacement. Infections rates following arthroplasty range from 0.5% to 3%. The acutely infected knee replacement often presents ... -
Management of children with type 1 diabetes during illness: a national survey.
(BMJ, 2016-02-22)Adequate sick-day management at home can reduce the risk of progression to diabetic ketoacidosis and admission to hospital. The aim of this project was to review the management of diabetes during illness. -
Management of common infections in pregnancy
(Sage, 2016-03-09)Pregnant women are peculiarly vulnerable to infections – the mechanism for this is multi-factorial and includes immune tolerance to the fetus (and placenta) itself, and maternal physiological changes, such as urinary stasis ... -
Management of extensive intraparotid vascular malformation: a case report
(Wolters Kluwer, 2014-06) -
Management of hypothyroidism in pregnancy: we must do better.
(Wiley, 2013-03) -
Management of paediatric hernia.
(BMJ, 2017-10-19) -
Management of patients in a combined thyroid eye clinic in secondary care
(Springer, 2014-02-01)The European Group on Graves' Orbitopathy (EUGOGO) recommends the use of specialised multidisciplinary clinics for the management of thyroid eye disease (TED). In the UK, many patients with TED are managed outside of ... -
Management of patients with Graves' orbitopathy: initial assessment, management outside specialised centres and referral pathways
(Royal College of Physicians, 2015-04-01)Graves' orbitopathy (GO) is uncommon, but responsible for considerable morbidity. A coordinated approach between healthcare professionals is required in order to meet the needs of patients. Early diagnosis can be achieved ... -
Management of periprosthetic joint infection after total hip arthroplasty using a custom made articulating spacer (CUMARS); the Exeter experience
(Elsevier, 2014-09-17)Periprosthetic joint infection (PJI) after THA is a major complication with an incidence of 1%-3%. We report our experiences with a technique using a custom-made articulating spacer (CUMARS) at the first of two-stage ... -
Management of sulfonylurea-treated monogenic diabetes in pregnancy: implications of placental glibenclamide transfer.
(Wiley, 2017-05-30)The optimum treatment for HNF1A/HNF4A maturity-onset diabetes of the young and ATP-sensitive potassium (KATP ) channel neonatal diabetes, outside pregnancy, is sulfonylureas, but there is little evidence regarding the most ... -
Management of thyroid eye disease in the United Kingdom: A multi-centre thyroid eye disease audit.
(Taylor and Francis, 2017-03-15)This article provides baseline data and highlight any major deficiencies in the current level of care provided for adult patients with thyroid eye disease (TED). We used prospective nonrandomized cross-sectional multicenter ... -
Managing frostbite in a South African patient.
(Wiley, 2013-08)This report focuses on a 23-year-old man of African-Caribbean origin who presented to a Burns unit with soft-tissue loss following a road traffic collision (RTC) in an extremely cold weather. Having been involved in the ...