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Now showing items 1862-1881 of 3408
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Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits
(Public Library of Science, 2020-08-14)Genetic studies have recently highlighted the importance of fat distribution, as well as overall adiposity, in the pathogenesis of obesity-associated diseases. Using a large study (n = 1,288) from 4 independent cohorts, ... -
Machine Learning in Aging Research
(Silverchair Information Systems, 2019-11-13) -
Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score
(Wiley, 2021-07-06)To support the global restart of elective surgery, data from an international prospective cohort study of 8492 patients (69 countries) was analysed using artificial intelligence (machine learning techniques) to develop a ... -
MAFA missense mutation causes familial insulinomatosis and diabetes mellitus.
(Proceedings of the National Academy of Sciences of the USA, 2018-01-30)The β-cell-enriched MAFA transcription factor plays a central role in regulating glucose-stimulated insulin secretion while also demonstrating oncogenic transformation potential in vitro. No disease-causing MAFA variants ... -
Magnet Fracture within a Magnetically Controlled Growing Rod: A Case Report of a New Mechanism of Failure
(Indian Orthopaedic Research Group, 2021-08-01)Introduction: Magnetically controlled growing rods (MCGRs) have been widely adopted in the management of early-onset scoliosis since they were first described in 2012. Recent reports have highlighted concerns around their ... -
The magnetic resonance imaging appearance of the anterolateral ligament of the knee in association with anterior cruciate rupture.
(Springer, 2017-04-21)The magnetic resonance imaging (MRI) appearance of the anterolateral ligament (ALL) has been described. However, the appearance of this structure and injury, in the presence of anterior cruciate ligament (ACL) injury, is ... -
Magnetically controlled growing rods in the treatment of early-onset scoliosis: a note of caution.
(British Editorial Society of Bone and Joint Journal, 2017-06)The MAGnetic Expansion Control (MAGEC) system is used increasingly in the management of early-onset scoliosis. Good results have been published, but there have been recent reports identifying implant failures that may be ... -
Maintaining ear aesthetics in helical rim reconstruction
(Wolters Kluwer, 2014-03-01)BACKGROUND: Wedge resections of the helical rim may result in a significant deformity of the ear with the ear not only smaller but cupped and prominent too. Our technique involves resection of the wedge in the scaphal area ... -
Major surgery induces acute changes in measured DNA methylation associated with immune response pathways
(Nature Publishing Group, 2020-04-01)Surgery is an invasive procedure evoking acute inflammatory and immune responses that can influence risk for postoperative complications including cognitive dysfunction and delirium. Although the specific mechanisms driving ... -
The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells.
(Springer, 2014-01)Classically, type 1 diabetes is thought to proceed to absolute insulin deficiency. Recently developed ultrasensitive assays capable of detecting C-peptide under 5 pmol/l now allow very low levels of C-peptide to be detected ... -
Making an impact: Exploring delegates' perceptions of the clinical governance development programme
(Unknown, 2003-09-01)Aims to identify the positive and negative impact that the NHS Clinical Governance Support Team's (CGST) Clinical Governance Development Programme (CGDP) was perceived to have (or failed to have) on delegates, working ... -
Making connections: Social identification with new treatment groups for lifestyle management of severe obesity
(Wiley, 2020-04-08)Groups are regularly used to deliver healthcare services, including the management of obesity, and there is growing evidence that patients' experiences of such groups fundamentally shape treatment effects. This study ... -
Malignant melanoma: Claims and controversies
(Sage, 2018-08-13) -
A man with paraesthesia, headache, and vertigo.
(BMJ, 2017-11-23) -
Management and care of patients with vulval conditions
(The British Dermatological Nursing Group, 2020-09) -
Management and outcomes in critically ill nonagenarian versus octogenarian patients
(BioMed Central, 2021-10-19)BACKGROUND: Intensive care unit (ICU) patients age 90 years or older represent a growing subgroup and place a huge financial burden on health care resources despite the benefit being unclear. This leads to ethical problems. ... -
Management of acute periprosthetic joint infection of the knee - Algorithms for the on call surgeon.
(Elsevier, 2016-06-23)Periprosthetic joint infection (PJI) remains a serious complication following a total knee replacement. Infections rates following arthroplasty range from 0.5% to 3%. The acutely infected knee replacement often presents ... -
Management of Acutely Symptomatic Hernia (MASH) study
(Wiley, 2022-07-15)BACKGROUND: Acutely symptomatic abdominal wall and groin hernias are a common reason for acute surgical hospital admissions. There are limited data to guide the treatment of these patients. This study aimed to assess ... -
Management of Behavioral and Psychological Symptoms in People With Alzheimer's Disease: An International Delphi Consensus
(Cambridge University Press, 2019-01)Behavioral and psychological symptoms of dementia (BPSD) are nearly universal in dementia, a condition occurring in more than 40 million people worldwide. BPSD present a considerable treatment challenge for prescribers and ... -
Management of children and young people with idiopathic pituitary stalk thickening, central diabetes insipidus, or both: a national clinical practice consensus guideline.
(Elsevier, 2021-06-29)Unexplained or idiopathic pituitary stalk thickening or central diabetes insipidus not only harbours rare occult malignancies in 40% of cases but can also reflect benign congenital defects. Between 2014 and 2019, a ...