Browsing by Title
Now showing items 552-571 of 2543
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Day case laparoscopic cholecystectomy: Safety and feasibility in obese patients.
(Elsevier, 2017-12-09)Day-case laparoscopic cholecystectomy (DCLC) is not universally adopted and its use is limited to patients selected by non-standardized criteria. Since laparoscopic cholecystectomy is considered technically more difficult ... -
Decreased tibial nerve movement in patients with failed back surgery syndrome and persistent leg pain
(Springer, 2019-07)Purpose To measure and compare the total and normalised tibial nerve movements during forward bending in patients with and without failed back surgery syndrome (FBSS) and persistent leg pain following anatomically successful ... -
Deep and Frequent Phenotyping study protocol: an observational study in prodromal Alzheimer's disease
(BMJ, 2019-03-23)Introduction: Recent failures of potential novel therapeutics for Alzheimer's disease (AD) have prompted a drive towards clinical studies in prodromal or preclinical states. However, carrying out clinical trials in early ... -
A Deep Intronic HADH Splicing Mutation (c.636+471G>T) in a Congenital Hyperinsulinemic Hypoglycemia Case: Long Term Clinical Course.
(Galenos, 2015-06)Unlike other congenital fatty acid oxidation defects, short-chain L-3-hydroxyacyl-CoA (SCHAD, HADH) deficiency is characterised by hypoglycemia with hyperinsulinism in the neonatal or infancy periods. The long-term and ... -
Deep phenotyping of fourteen new patients with IQSEC2 variants, including monozygotic twins of discordant phenotype
(Wiley, 2019-04)Whole exome sequencing has established IQSEC2 as a neurodevelopmental disability gene. The IQSEC2 variant phenotype includes developmental delay, intellectual disability, epilepsy, hypotonia, autism, developmental regression, ... -
Defining a New Prognostic index for Stage I Non-seminomatous Germ Cell Tumors using CXCL12 Expression and Proportion of Embyronal Carcinoma
(Clinical Cancer Research, 2015-10-09)PURPOSE: Up to 50% of patients diagnosed with stage I non-seminomatous germ cell tumors (NSGCT) harbor occult metastases. Patients are managed by surveillance with chemotherapy at relapse or adjuvant treatment up-front. ... -
Defining drug response for stratified medicine.
(Elsevier, 2017-01)The premise for stratified medicine is that drug efficacy, drug safety, or both, vary between groups of patients, and biomarkers can be used to facilitate more targeted prescribing, with the aim of improving the benefit:risk ... -
Defining left ventricular remodeling following acute ST-segment elevation myocardial infarction using cardiovascular magnetic resonance.
(BioMed Central, 2017-03-13)The assessment of post-myocardial infarction (MI) left ventricular (LV) remodeling by cardiovascular magnetic resonance (CMR) currently uses criteria defined by echocardiography. Our aim was to provide CMR criteria for ... -
Defining the genetic aetiology of monogenic diabetes can improve treatment.
(Taylor & Francis, 2006-09)A molecular genetic diagnosis is now possible for > 80% of patients with monogenic diabetes. This not only provides accurate information regarding inheritance and prognosis, but can inform treatment decisions and improve ... -
Defining the role of common variation in the genomic and biological architecture of adult human height
(Nature, 2014-11)Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in ... -
Definitions for loss of domain: an International Delphi Consensus of Expert Surgeons
(Springer, 2020-04)No standardized written or volumetric definition exists for 'loss of domain' (LOD). This limits the utility of LOD as a morphological descriptor and as a predictor of peri- and postoperative outcomes. Consequently, our aim ... -
Delayed absorbable synthetic plug (GORE BIO-A ) for the treatment of fistula in ano: a systematic review
(Wiley, 2016-01-04)AIM: Recent advances in the treatment of fistula-in-ano have focused on surgical techniques that preserve sphincter integrity. Plugs that obliterate the lumen of the fistula track have been proposed as one such method and ... -
Delineating the expanding phenotype associated with SCAPER gene mutation
(Wiley, 2019-08) -
Delineation of dominant and recessive forms of LZTR1-associated Noonan syndrome
(Wiley, 2019-06)Noonan syndrome (NS) is characterised by distinctive facial features, heart defects, variable degrees of intellectual disability and other phenotypic manifestations. Although the mode of inheritance is typically dominant, ... -
Delving Deep into the Proteome of Lung Fibrosis Brings Plasma Cells to the Surface.
(ATS Journals, 2017-07-11) -
Dementia Care Mapping™ to reduce agitation in care home residents with dementia: the EPIC cluster RCT
(NIHR Journals Library, 2020-03)Background: The quality of care for people with dementia in care homes is of concern. Interventions that can improve care outcomes are required. Objective: To investigate the clinical effectiveness and cost-effectiveness ... -
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
(Elsevier Science, 2020-08-08) -
Dental amalgam tattoo consequent to a human bite injury
(Elsevier, 2005-12)