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Now showing items 28-47 of 3226
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A 2021 consensus statement on osteotomies around the knee by the UK Knee Osteotomy consensus Group (KOG)
(Elsevier, 2021-09-22)BACKGROUND: There are significant deficiencies in the evidence base of modern-day osteotomy which result in significant variation in practice between surgeons. The purpose of this statement was to develop a consensus ... -
A biallelic SNIP1 Amish founder variant causes a recognizable neurodevelopmental disorder
(PLoS One, 2021-09-01)SNIP1 (Smad nuclear interacting protein 1) is a widely expressed transcriptional suppressor of the TGF-β signal-transduction pathway which plays a key role in human spliceosome function. Here, we describe extensive genetic ... -
A case of avian influenza A(H5N1) in England, January 2022
(Unknown, 2022-02-01)On 5 January 2022, high pathogenicity avian influenza A(H5N1) was confirmed in an individual who kept a large flock of ducks at their home in England. The individual remained asymptomatic. H5N1 was confirmed in 19/20 sampled ... -
A comparative study of treadmill tests and heel raising exercise for peripheral arterial disease
(Elsevier, 1997-03-01)OBJECTIVES: This two part study validated a 1 min treadmill exercise test and compared this with simple heel raising exercise. METHODS: In an initial study of 24 claudicants (aged 43-79, median 63 years), ankle pressures ... -
A comparison of surgical practice and operative outcomes between retroperitoneal and transperitoneal laparoscopic nephrectomies – 6 years of data from the BAUS Nephrectomy database
Objectives:While the choice of surgical approach for laparoscopic nephrectomy is broadly split between transperitoneal and retroperitoneal options, the evidence for the impact of this decision on perioperative outcomes is ... -
A cost consequence study of the impact of a dermatology-trained practice nurse on the quality of life of primary care patients with eczema and psoriasis
(Royal College of General Practitioners, 2000-08-24)BACKGROUND: The practice nurse is central to the development of a primary care-led National Health Service. Skin diseases can have a major impact on patients' lives but general practitioners (GPs) lack many of the skills ... -
A dosimetric study to improve the quality of nodal radiotherapy in breast cancer
(British Institute of Radiology, 2021-08-13)OBJECTIVES: Field-based planning for regional nodal breast radiotherapy (RT) used to be standard practice. This study evaluated a field-based posterior axillary boost (PAB) and two forward-planned intensity-modulated RT ... -
A feasibility study of multisite networked digital pathology reporting in England
(Medknow Publications, 2022-01-01)<b>Background:</b> The objective of the project was to evaluate the feasibility of introducing a single-networked digital histopathology reporting platform in the Southwest Peninsula region of England by allowing pathologists ... -
A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor
(PLoS One, 2021-06-10)Frozen shoulder is a painful condition that often requires surgery and affects up to 5% of individuals aged 40–60 years. Little is known about the causes of the condition, but diabetes is a strong risk factor. To begin to ... -
A hemizygous mutation in the FOXP3 gene (IPEX syndrome) resulting in recurrent X-linked fetal hydrops: a case report
(Springer, 2021-02-26)Fetal hydrops is excessive extravasation of fluid into the third space in a fetus, which could be due to a wide differential of underlying pathology. IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) ... -
A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex
(Nature, 2021-06-10)Epigenome-wide association studies of Alzheimer's disease have highlighted neuropathology-associated DNA methylation differences, although existing studies have been limited in sample size and utilized different brain ... -
A modified Delphi process to establish research priorities in hernia surgery
(Springer, 2021-10-21)BACKGROUND: Abdominal wall hernia repair is one of the most commonly performed surgical procedures worldwide, yet despite this, there remains a lack of high-quality evidence to support best management. The aim of the study ... -
A multicenter randomized controlled trial indicates that paclitaxel-coated balloons provide no benefit for arteriovenous fistulas
(Elsevier, 2021-03-27)The role of paclitaxel-coated balloons has been established in the coronary and peripheral arterial circulations with recent interest in the use of paclitaxel-coated balloons to improve patency rates following angioplasty ... -
A Multicentre Retrospective Analysis of Toxicity in 6-weekly Versus 3-weekly Pembrolizumab
(Elsevier, 2021-05-01)Pembrolizumab is an anti-programmed cell death protein 1 immune checkpoint inhibitor with a dosing schedule of 200 mg 3 weekly (q3w). Dose of 400 mg 6 weekly (q6w) was approved based on simulation of dose/exposure relationships ... -
A multiple sclerosis nurse specialist narrative, focusing on supporting people to manage cognitive changes
(Mark Allen Group, 2022-01-01)Background: Cognitive changes are common in people with multiple sclerosis (MS). Interventions from health professionals can focus on assessment, measurement and advice on management strategies. Such interventions are often ... -
A national retrospective study of the association between serious operational problems and COVID-19 specific intensive care mortality risk
(PLoS One, 2021-07-29)OBJECTIVES: To describe the relationship between reported serious operational problems (SOPs), and mortality for patients with COVID-19 admitted to intensive care units (ICUs). DESIGN: English national retrospective cohort ... -
A New Era in Epicardial Access for the Ablation of Ventricular Arrhythmias: The Epi-Co(2) Registry
(JACC, 2021-01-01)OBJECTIVES: This multicenter registry aimed to assess the reproducibility and safety of intentional coronary vein exit and carbon dioxide insufflation to facilitate subxiphoid epicardial access in the setting of ventricular ... -
A novel algorithmic approach to generate consensus treatment guidelines in adult acute myeloid leukaemia
(Wiley, 2021-12-26)Induction therapy for acute myeloid leukaemia (AML) has changed with the approval of a number of new agents. Clinical guidelines can struggle to keep pace with an evolving treatment and evidence landscape and therefore ...