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Now showing items 2749-2768 of 2827
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The V-Y capsulotomy release for correcting capsular contracture.
(Elsevier, 2015-12) -
VAC it – Some Techniques on the Application of VAC Dressings
(Royal College of Surgeons, 2008-03) -
Vaginal microbiota and human papillomavirus: a systematic review
(Galenos, 2019-09)Accumulating evidence indicates the potential correlation between the vaginal microbioma and the acquisition and persistence of Human Papillomavirus (HPV) infection. This study has as intention to demonstrate the potential ... -
Validating the portal population of the United Kingdom Multiple Sclerosis Register.
(Elsevier, 2018-05-25)The UK Multiple Sclerosis Register (UKMSR) is a large cohort study designed to capture 'real world' information about living with multiple sclerosis (MS) in the UK from diverse sources. The primary source of data is directly ... -
Validating the positivity thresholds of drug-tolerant anti-infliximab and anti-adalimumab antibody assays
(Wiley, 2021-01)Background: When used proactively, drug-tolerant anti-tumour necrosis factor (TNF) antibody assays provide early opportunity to suppress immunogenicity. Aim: To validate positivity thresholds of IDKmonitor drug-tolerant ... -
Validation of a single-sample urinary C-peptide creatinine ratio as a reproducible alternative to serum C-peptide in patients with Type 2 diabetes.
(Wiley, 2012-01)Serum C-peptide can be used in Type 2 diabetes as a measure of endogenous insulin secretion, but practicalities of collection limit its routine clinical use. Urine C-peptide creatinine ratio is a non-invasive alternative ... -
Validation of inertial measurement units with optical tracking system in patients operated with Total hip arthroplasty
(BioMed Central, 2019-02-06)Patient reported outcome measurement (PROMs) will not capture in detail the functional joint motion before and after total hip arthroplasty (THA). Therefore, methods more specifically aimed to analyse joint movements may ... -
Validation of subscales of the Severe Asthma Questionnaire (SAQ) using exploratory factor analysis (EFA)
(BioMed Central, 2020-10-09)Background: The Severe Asthma Questionnaire (SAQ) is a health related quality of life (HRQoL) questionnaire validated for use in severe asthma. It is scored using the mean value of 16 items (SAQ score) in addition to a ... -
The Value of Coenzyme Q10 Determination in Mitochondrial Patients.
(MDPI, 2017-03-24)Coenzyme Q10 (CoQ) is a lipid that is ubiquitously synthesized in tissues and has a key role in mitochondrial oxidative phosphorylation. Its biochemical determination provides insight into the CoQ status of tissues and may ... -
The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2-W68G mutation.
(Wiley, 2015-10)In infants, especially with novel previously undescribed mutations of the KATP channel causing neonatal diabetes, in vitro studies can be used to both predict the response to sulphonylurea treatment and support a second ... -
Variability in thyroid function test requests across general practices in south-west England.
(Radcliffe Publishing, 2013)The number of thyroid function tests (TFTs) performed in the UK and other countries has increased considerably in recent years. Inconsistent clinical practice associated with inappropriate requests for tests is thought to ... -
Variable DNA methylation in neonates mediates the association between prenatal smoking and birth weight
(The Royal Society Publishing, 2019-04-15)There is great interest in the role epigenetic variation induced by non-genetic exposures may play in the context of health and disease. In particular, DNA methylation has previously been shown to be highly dynamic during ... -
Variable Phenotype of Diabetes Mellitus in Siblings with a Homozygous PTF1A Enhancer Mutation.
(Karger, 2015)Neonatal diabetes is a rare form of diabetes, characterized by onset in the first 6 months of life. A number of cases are due to pancreas agenesis. Recently, PTF1A enhancer mutations have been shown to cause neonatal ... -
Variants in GNAI1 cause a syndrome associated with variable features including developmental delay, seizures, and hypotonia.
(Nature, 2021-05-01)PURPOSE: Neurodevelopmental disorders (NDDs) encompass a spectrum of genetically heterogeneous disorders with features that commonly include developmental delay, intellectual disability, and autism spectrum disorders. We ... -
Variants in KCNJ11 and BAD do not predict response to ketogenic dietary therapies for epilepsy.
(Elsevier, 2015-12)In the absence of specific metabolic disorders, predictors of response to ketogenic dietary therapies (KDT) are unknown. We aimed to determine whether variants in established candidate genes KCNJ11 and BAD influence response ... -
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
(Nature, 2019-09)The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm ... -
Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.
(Springer, 2016-03-10)Genome-wide association (GWA) studies have identified hundreds of common genetic variants associated with obesity and type 2 diabetes. These studies have usually focused on additive association tests. Identifying deviations ... -
Variation in 5-hydroxymethylcytosine across human cortex and cerebellum.
(BioMed Central, 2016-02-16)The most widely utilized approaches for quantifying DNA methylation involve the treatment of genomic DNA with sodium bisulfite; however, this method cannot distinguish between 5-methylcytosine (5mC) and 5-hydroxymethylcytosine ... -
Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by SLC29A4) and Organic Cation Transporter 1 (OCT1) (Encoded by SLC22A1) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study
(the American Diabetes Association, 2019-06)Objective: Gastrointestinal adverse effects occur in 20-30% of patients with metformin-treated type 2 diabetes, leading to premature discontinuation in 5-10% of the cases. Gastrointestinal intolerance may reflect localized ... -
Variation in the provision and practice of implant-based breast reconstruction in the UK: Results from the iBRA national practice questionnaire.
(Elsevier, 2017-10)The introduction of biological and synthetic meshes has revolutionised the practice of implant-based breast reconstruction (IBBR) but evidence for effectiveness is lacking. The iBRA (implant Breast Reconstruction evAluation) ...