Browsing by Title
Now showing items 3302-3321 of 3493
-
UK consensus recommendations for clinical management of cancer risk for women with germline pathogenic variants in cancer predisposition genes: RAD51C, RAD51D, BRIP1 and PALB2
(BMJ, 2022-11-21)Germline pathogenic variants (GPVs) in the cancer predisposition genes BRCA1, BRCA2, MLH1, MSH2, MSH6, BRIP1, PALB2, RAD51D and RAD51C are identified in approximately 15% of patients with ovarian cancer (OC). While there ... -
UK guidelines on the management of variceal haemorrhage in cirrhotic patients
(BMJ, 2015-11-01)These updated guidelines on the management of variceal haemorrhage have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the ... -
UK national bladder outlet obstruction surgery snapshot audit
(Wiley, 2021-10-07)OBJECTIVES: To determine the preoperative assessment and perioperative outcomes of men undergoing bladder outlet obstruction (BOO) surgery in the UK. PATIENTS AND METHODS: A retrospective cohort study was conducted of all ... -
UK recommendations for SDHA germline genetic testing and surveillance in clinical practice
(BMJ, 2022-03-08)SDHA pathogenic germline variants (PGVs) are identified in up to 10% of patients with paraganglioma and phaeochromocytoma and up to 30% with wild-type gastrointestinal stromal tumours. Most SDHA PGV carriers present with ... -
UK Royal Society of Medicine Venous Forum VTE Advice 2020
(Atypon, 2021-03) -
UK trainee experience in interstitial lung disease: results from a British Thoracic Society survey
(BMJ, 2015-02-01)Interstitial lung disease (ILD) is a growing field of respiratory medicine in which novel therapies are emerging. It is important that trainees gain competence and confidence in this area. To explore the training experiences ... -
UKCGG Consensus Group guidelines for the management of patients with constitutional TP53 pathogenic variants
(BMJ, 2020-06-22)Constitutional pathogenic variants in TP53 are associated with Li-Fraumeni syndrome or the more recently described heritable TP53-related cancer syndrome and are associated with increased lifetime risks of a wide spectrum ... -
Ultra-high-resolution time-frequency analysis of EEG to characterise brain functional connectivity with the application in Alzheimer's disease
(IOP Publishing, 2022-08-11)Objective.This study aims to explore the potential of high-resolution brain functional connectivity based on electroencephalogram, a non-invasive low-cost technique, to be translated into a long-overdue biomarker and a ... -
Ultrasonography guided peritendinous anaesthetic infiltration in hamstrings autograft anterior cruciate ligament reconstruction
(Royal College of Surgeons, 2014-07-01) -
Ultrasonography guided rectus sheath catheters versus epidural analgesia for open colorectal cancer surgery in a single centre.
(Royal College of Surgeons, 2013-11)Epidural anaesthesia (EA) has been the accepted standard for postoperative analgesia in open abdominal surgery. However, it is not without significant risk. This study aimed to audit the effect of EA and ultrasonography ... -
Ultrasound dimensions of the rotator cuff in young healthy adults
(Elsevier, 2014-08-01)BACKGROUND: No studies have looked at the rotator cuff dimensions in the young healthy population using ultrasonography. Our aim is to define the ultrasound dimensions of the rotator cuff in the healthy young adult population ... -
Ultrasound-directed reduction of distal radius fractures in adults: a systematic review.
(BMJ, 2021-04-14)OBJECTIVE: To conduct a systematic review of the clinical literature to determine whether ultrasound can be used to improve the reduction of distal radius fractures in adults in the ED. METHODOLOGY: A study protocol was ... -
UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking
(American Society for Clinical Investigation, 2022-05-16)Variants in the UNC45A cochaperone have been recently associated with a syndrome combining diarrhea, cholestasis, deafness, and bone fragility. Yet the mechanism underlying intestinal failure in UNC45A deficiency remains ... -
Uncovering the burden of hidden ciliopathies in the 100 000 Genomes Project: a reverse phenotyping approach
(BMJ, 2022-06-28)BACKGROUND: The 100 000 Genomes Project (100K) recruited National Health Service patients with eligible rare diseases and cancer between 2016 and 2018. PanelApp virtual gene panels were applied to whole genome sequencing ... -
Undergraduate Suture and Local Anesthetic Training in the United Kingdom.
(Elsevier, 2016-05-17) -
Understanding anti-TNF treatment failure: does serum triiodothyronine-to-thyroxine (T3/T4) ratio predict therapeutic outcome to anti-TNF therapies in biologic-naïve patients with active luminal Crohn's disease?
(Wiley, 2022-09-01)BACKGROUND: During illness, adaptations of the hypothalamic-pituitary-thyroid axis reduce energy expenditure, protein catabolism and modulate immune responses to promote survival. Lower serum free triiodothyronine-to-thyroxine ... -
Understanding Factors That Cause Tinnitus: A Mendelian Randomization Study in the UK Biobank.
(Lippincott, Williams & Wilkins, 2021-06-08)OBJECTIVES: To investigate the causal role of established risk factors and associated conditions to tinnitus and tinnitus severity in the UK Biobank. DESIGN: The prospective cohort study with large dataset of >500,000 ... -
Understanding fear and anxiety in patients at the time of an exacerbation of chronic obstructive pulmonary disease: a qualitative study.
(Sage, 2015-12)To determine the importance of fear and anxiety at the time of an exacerbation of chronic obstructive pulmonary disease. To assess the influence of carers and health professionals on this fear and anxiety.