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Now showing items 1864-1883 of 2827
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p.Val804Met, the most frequent pathogenic mutation in RET, confers a very low lifetime risk of medullary thyroid cancer.
(Endocrine Society, 2018-03-23)To date, penetrance figures for medullary thyroid cancer (MTC) for variants in RET have been estimated from families ascertained on account of presence of MTC. -
P046. Radiofrequency seeds compared with wire-guided localisation for occult breast lesions: Initial experience
(Elsevier, 2021-05-01)Introduction: Wire guided localisation (WGL) has been the mainstay for localisation for clinically occult breast lesions, though scheduling issues remain, particularly during covid-19. Hologic LOCalizer uses radiofrequency ... -
P100. High wavenumber Raman spectroscopy tissue differentiation for intraoperative margin analysis
(Elsevier, 2021-05-01)Introduction: Re-excision for positive margins occurs in almost 20% of patients undergoing Breast Conserving Surgery (BCS) with high institutional cost and patient psychological burden. High wavenumber Raman Spectroscopy ... -
P181 Patient-led remote intracapillary pharmacokinetic sampling (fingerPRICKS) for therapeutic drug monitoring in patients with Inflammatory Bowel Disease
(Oxford University Press, 2021-05-01)Because of COVID-19 public health restrictions, telemedicine has replaced conventional outpatient follow up for most patients with chronic immune-mediated inflammatory disorders treated with biologic drugs. Innovative ... -
P208 Correlation between physician and patient disease assessments in ulcerative colitis: 2-year UK data from the ICONIC study
(Oxford University Press, 2020-01-15)Background ICONIC is the largest prospective multi-country (n = 33) observational study assessing burden in adult ulcerative colitis (UC) patients under routine care. Both patient and physician assessments of disease ... -
P246 Development of a new Inflammatory Bowel Disease Patient Identifier shortens time to clinic review and initiation of treatment
(Oxford University Press, 2021-05-01)Timely diagnosis of inflammatory bowel disease (IBD) is important because earlier use of biologic therapies leads to mucosal healing, a reduction in hospitalisations and surgeries and improvements in quality of life. In ... -
P387 Depression in biologic-treated patients with inflammatory bowel disease during the COVID19 pandemic
(Oxford University Press, 2021-05-01)Given the existential threat from COVID-19 and the consequent restrictive public health measures it is perhaps unsurprising that SARS-CoV-2 infection has been linked to increases in rates of depression in the general ... -
P413 Exclusive enteral nutrition provides an effective bridge to safer interval elective surgery for Crohn's disease
(Oxford Journals, 2017-02-01) -
P550 Clinical features of demyelination following anti-TNFα therapy.
(Oxford Journals, 2017-02) -
P648 The impact of infliximab therapeutic drug monitoring on decisions made in a virtual biologics clinic for IBD
(Oxford Journals, 2017-02-01) -
P92 Real-world effectiveness of tofacitinib for moderate to severe ulcerative colitis: a multi-centre UK experience
(BMJ, 2021-01-01)Introduction Tofacitinib is an oral partially selective Janus kinase inhibitor approved for the treatment of refractory moderate to severe ulcerative colitis (UC). Real-world experience of patients with UC treated with ... -
Pacemaker battery scandal.
(BMJ, 2016-02-04) -
Paediatric procedural sedation using ketamine in a UK emergency department: a 7 year review of practice.
(Oxford Journals, 2016-02-17)Ketamine is growing in popularity for procedural sedation in the paediatric population, yet safety concerns remain. We performed a retrospective review of practice and outcomes of paediatric ketamine sedation using the ... -
Paired rRNA-depleted and polyA-selected RNA sequencing data and supporting multi-omics data from human T cells
(Nature Publishing Group, 2020-11-09)Both poly(A) enrichment and ribosomal RNA depletion are commonly used for RNA sequencing. Either has its advantages and disadvantages that may lead to biases in the downstream analyses. To better access these effects, we ... -
Palliative Care for COPD: Signs of Progress, but Still a Long Way to Go.
(American Thoracic Society, 2018-06-11) -
Palliative care for people with COPD: effective but underused.
(European Respiratory Society, 2018-02) -
Palliative care in liver disease: what does good look like?
(BMJ, 2019-09)The mortality rate from chronic liver disease in the UK is rising rapidly, and patients with advanced disease have a symptom burden comparable to or higher than that experienced in other life-limiting illnesses. While ...