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Now showing items 2201-2220 of 3493
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O11 Outcomes of GP outreach programme offering colonoscopic surveillance for IBD patients managed in primary care
(BMJ, 2021-01-01)Introduction Colonoscopic surveillance in IBD patients can reduce the development of colorectal cancer (CRC) and the rate of CRC-associated death. We recently reported that 27% of IBD patients living in East Devon are ... -
Obesity alone should not rule out knee replacement surgery
(BMJ, 2022-10-25)The studyEvans JT, Mouchti S, Blom AW, et al. Obesity and revision surgery, mortality, and patient-reported outcomes after primary knee replacement surgery in the National Joint Registry: a UK cohort study. PLoS Med 2021;18:7. -
Obesity and colorectal liver metastases: Mechanisms and management
(Elsevier, 2016-05-20)Colorectal cancer (CRC) is the third commonest malignancy after lung and breast cancer. The most common cause of mortality from CRC is from distant metastases. Obesity is a known risk factor for primary CRC development. ... -
Obesity and Longer Term Risks of Dementia in 65-74 Year Olds
(Oxford University Press, 2019-05-01)Background: overweight or obesity at ages <65 years associates with increased dementia incidence, but at ≥65 years estimates are paradoxical. Weight loss before dementia diagnosis, plus smoking and diseases causing weight ... -
Obesity impacts the regulation of miR-10b and its targets in primary breast tumors
(BioMed Central, 2019-01)Obesity increases breast cancer (BC) risk in post-menopausal women by mostly unknown molecular mechanisms which may partly be regulated by microRNAs (miRNAs). We isolated RNA from paired benign and malignant biopsies from ... -
Obesity in Older People With and Without Conditions Associated With Weight Loss: Follow-up of 955,000 Primary Care Patients.
(Oxford Academic, 2017-02)Moderate obesity in later life may improve survival, prompting calls to revise obesity control policies. However, this obesity paradox may be due to confounding from smoking, diseases causing weight-loss, plus varying ... -
Objective responses to first-line neoadjuvant carboplatin-paclitaxel regimens for ovarian, fallopian tube, or primary peritoneal carcinoma (ICON8): post-hoc exploratory analysis of a randomised, phase 3 trial
(Elsevier, 2021-02-01)BACKGROUND: Platinum-based neoadjuvant chemotherapy followed by delayed primary surgery (DPS) is an established strategy for women with newly diagnosed, advanced-stage epithelial ovarian cancer. Although this therapeutic ... -
Obstructive sleep apnea syndrome with bilateral papilledema and vision loss in a 3-year-old child.
(Elsevier, 2008-04)We describe bilateral papilledema and vision loss in a 3-year-old child with obstructive sleep apnea. Although lumbar puncture initially disclosed a normal opening pressure, cerebrospinal fluid (CSF) pressure monitoring ... -
Ocular manifestations of tuberculosis: an update
(Taylor & Francis, 2016-02-18)Tuberculosis (TB) remains a major global health burden and has both pulmonary and extra-pulmonary manifestations. One well-recognised and complex extra-pulmonary form is ocular TB, with its diverse extra- and intra-ocular ... -
Oedema management in a diabetic patient with foot ulceration and peripheral vascular disease: a case study
(SB Communications Group, 2016)Peripheral oedema is a recognised complication in prolonging wound healing. Despite this, there is little evidence available on the use of compression therapy in the presence of diabetic foot disease. The case study outlined ... -
Offspring birthweight is not associated with paternal insulin resistance
(Springer, 2006-09-06)AIMS/HYPOTHESIS: Low birthweight is associated with insulin resistance and other insulin resistance-related phenotypes: diabetes, hypertension, and vascular disease in later life. The underlying mechanism is unclear. The ... -
Offspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass
(MDPI, 2019-03)Low birth weight is a risk factor for gestational and type 2 diabetes (T2D). Since mammalian target of rapamycin (mTOR) controls pancreatic β-cell mass and hormone release, we hypothesized that nutritional insult in utero ... -
Olaratumab in Combination with Doxorubicin for the Treatment of Advanced Soft Tissue Sarcoma: An Evidence Review Group Perspective of a National Institute for Health and Care Excellence Single Technology Appraisal.
(Springer, 2017-09-15)The manufacturer of olaratumab (Lartruvo(®)), Eli Lilly & Company Limited, submitted evidence for the clinical and cost effectiveness of this drug, in combination with doxorubicin, for untreated advanced soft tissue sarcoma ... -
Old adversaries, modern mistakes: neurosyphilis.
(BMJ, 2013-06) -
On Picturing a Candle: The Prehistory of Imagery Science.
(Frontiers In Psychology, 2016-04-07)The past 25 years have seen a rapid growth of knowledge about brain mechanisms involved in visual mental imagery. These advances have largely been made independently of the long history of philosophical - and even psychological ... -
Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD.
(NEJM, 2018-05)The benefits of triple therapy for chronic obstructive pulmonary disease (COPD) with an inhaled glucocorticoid, a long-acting muscarinic antagonist (LAMA), and a long-acting β2-agonist (LABA), as compared with dual therapy ... -
Oncoplastic breast surgery: A guide to good practice.
(Elsevier, 2021-05-11)Oncoplastic Breast Surgery has become standard of care in the management of Breast. Cancer Patents. These guidelines written by an Expert Advisory Group; convened by the Association of Breast Surgery (ABS) and the British ... -
One- and two-stage surgical revision of peri-prosthetic joint infection of the hip: a pooled individual participant data analysis of 44 cohort studies.
(Springer, 2018-04-05)One-stage and two-stage revision strategies are the two main options for treating established chronic peri-prosthetic joint infection (PJI) of the hip; however, there is uncertainty regarding which is the best treatment ... -
One-stage or two-stage revision surgery for prosthetic hip joint infection - the INFORM trial: a study protocol for a randomised controlled trial.
(BioMed Central, 2016-02-17)Periprosthetic joint infection (PJI) affects approximately 1 % of patients following total hip replacement (THR) and often results in severe physical and emotional suffering. Current surgical treatment options are debridement, ... -
One-Stop Clinic Utilization in Plastic Surgery: Our Local Experience and the Results of a UK-Wide National Survey
(Hindawi, 2015-05-26)Introduction. "See and treat" one-stop clinics (OSCs) are an advocated NHS initiative to modernise care, reducing cancer treatment waiting times. Little studied in plastic surgery, the existing evidence suggests that though ...